Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients

Sigrid M.C. Broekaert; Katharina Flux; Liubov Kyrpychova; Denisa Kacerovska; Doina Ivan; Michael P. Schön; Philipp Ströbel; Michal Michal; Natalja Denisjuk; Katrin Kerl; Dmitry V. Kazakov

doi:10.1097/DAD.0000000000000651

Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients

Sigrid M.C. Broekaert, Katharina Flux, Liubov Kyrpychova, Denisa Kacerovska, Doina Ivan, Michael P. Schön, Philipp Ströbel, Michal Michal, Natalja Denisjuk, Katrin Kerl, Dmitry V. Kazakov

Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.

Original language	English (US)
Pages (from-to)	275-278
Number of pages	4
Journal	American Journal of Dermatopathology
Volume	39
Issue number	4
DOIs	https://doi.org/10.1097/DAD.0000000000000651
State	Published - Apr 1 2017

Keywords

appliqué pattern
eyelid
necrosis
periocular
sebaceous carcinoma
sebaceous differentiation
squared-off nuclei

ASJC Scopus subject areas

Pathology and Forensic Medicine
Dermatology

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10.1097/DAD.0000000000000651

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Broekaert, S. M. C., Flux, K., Kyrpychova, L., Kacerovska, D., Ivan, D., Schön, M. P., Ströbel, P., Michal, M., Denisjuk, N., Kerl, K., & Kazakov, D. V. (2017). Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients. American Journal of Dermatopathology, 39(4), 275-278. https://doi.org/10.1097/DAD.0000000000000651

Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients. / Broekaert, Sigrid M.C.; Flux, Katharina; Kyrpychova, Liubov et al.
In: American Journal of Dermatopathology, Vol. 39, No. 4, 01.04.2017, p. 275-278.

Research output: Contribution to journal › Article › peer-review

Broekaert, SMC, Flux, K, Kyrpychova, L, Kacerovska, D, Ivan, D, Schön, MP, Ströbel, P, Michal, M, Denisjuk, N, Kerl, K & Kazakov, DV 2017, 'Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients', American Journal of Dermatopathology, vol. 39, no. 4, pp. 275-278. https://doi.org/10.1097/DAD.0000000000000651

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abstract = "The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called {"}appliqu{\'e}{"} pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqu{\'e} pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.",

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AU - Broekaert, Sigrid M.C.

AU - Flux, Katharina

AU - Kyrpychova, Liubov

AU - Kacerovska, Denisa

AU - Ivan, Doina

AU - Schön, Michael P.

AU - Ströbel, Philipp

AU - Michal, Michal

AU - Denisjuk, Natalja

AU - Kerl, Katrin

AU - Kazakov, Dmitry V.

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N2 - The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.

AB - The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.

KW - appliqué pattern

KW - eyelid

KW - necrosis

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KW - sebaceous carcinoma

KW - sebaceous differentiation

KW - squared-off nuclei

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Squared-Off Nuclei and "appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms from 46 Patients

Abstract

Keywords

ASJC Scopus subject areas

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