Statins and cancer prevention

Marie France Demierre; Peter D.R. Higgins; Stephen B. Gruber; Ernest Hawk; Scott M. Lippman

doi:10.1038/nrc1751

Statins and cancer prevention

Marie France Demierre, Peter D.R. Higgins, Stephen B. Gruber, Ernest Hawk, Scott M. Lippman

Research output: Contribution to journal › Review article › peer-review

698 Scopus citations

Abstract

Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.

Original language	English (US)
Pages (from-to)	930-942
Number of pages	13
Journal	Nature Reviews Cancer
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nrc1751
State	Published - Dec 2005
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Statins and cancer prevention",

abstract = "Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.",

author = "Demierre, {Marie France} and Higgins, {Peter D.R.} and Gruber, {Stephen B.} and Ernest Hawk and Lippman, {Scott M.}",

note = "Funding Information: This work was supported in part by the University of Texas M.D. Anderson Cancer Center support grants from the National Cancer Institute, National Institutes of Health Department of Health and Human Services.",

year = "2005",

month = dec,

doi = "10.1038/nrc1751",

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T1 - Statins and cancer prevention

AU - Demierre, Marie France

AU - Higgins, Peter D.R.

AU - Gruber, Stephen B.

AU - Hawk, Ernest

AU - Lippman, Scott M.

N1 - Funding Information: This work was supported in part by the University of Texas M.D. Anderson Cancer Center support grants from the National Cancer Institute, National Institutes of Health Department of Health and Human Services.

PY - 2005/12

Y1 - 2005/12

N2 - Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.

AB - Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.

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Statins and cancer prevention

Abstract

ASJC Scopus subject areas

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