Stem cell factor

Ian K. McNiece; Robert A. Briddell

doi:10.1016/B978-012689663-3/50047-8

Stem cell factor

Ian K. McNiece, Robert A. Briddell

Stem Cell Transplantation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter deals with stem cell factor (SCF), which has been shown to be an essential growth factor in development, and maintenance of normal blood cell production. It synergizes with other hematopoietic growth factors to stimulate stem cells, primitive progenitor cells, and committed progenitor cells. Its clinical utility has been minimized by dose-limiting anaphylactoid reactions, however, clinical studies have demonstrated that in combination with granulocyte macrophage colony-stimulating factor (G-CSF), SCF can stimulate mobilization of increased numbers of CD34⁺ cells in peripheral blood progenitor cells (PBPC) products. If predictors of poor be a key growth factor for ex vivo manipulation of hematopoietic stem cells to produce regenerative tissues for various diseases mobilization can be developed. However, with the recent demonstration of plasticity of hematopoietic stem cells, generating cells of various tissues including, cardiac, neural, liver, lung, and endothelial cells. SCF may be a key growth factor for ex vivo manipulation of hematopoietic stem cells to produce regenerative tissues for various diseases.

Original language	English (US)
Title of host publication	The Cytokine Handbook
Publisher	Elsevier Inc.
Pages	1011-1016
Number of pages	6
ISBN (Electronic)	9780080518794
ISBN (Print)	9780126896633
DOIs	https://doi.org/10.1016/B978-012689663-3/50047-8
State	Published - Jul 7 2003

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1016/B978-012689663-3/50047-8

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Stem cell factor

Abstract

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