Stem cell potential of the mammalian gonad

Chia Feng Liu; Ivraym Barsoum; Rupesh Gupta; Marie Claude Hofmann; Humphrey Hung Chang Yao

Stem cell potential of the mammalian gonad

Chia Feng Liu, Ivraym Barsoum, Rupesh Gupta, Marie Claude Hofmann, Humphrey Hung Chang Yao

Research output: Contribution to journal › Review article › peer-review

Abstract

Stem cells have enormous potential for therapeutic application because of their ability to self-renew and differentiate into different cell types. Gonads, which consist of somatic cells and germ cells, are the only organs capable of transmitting genetic materials to the offspring. Germ-line stem cells and somatic stem cells have been found in the testis; however, the presence of stem cells in the ovary remains controversial. In this review, we discuss studies focusing on whether stem cell properties are present in the different cell types of male and female gonads and their implications on stem cell research.

Original language	English (US)
Pages (from-to)	510-518
Number of pages	9
Journal	Frontiers in Bioscience - Elite
Volume	1 E
Issue number	2
State	Published - Jun 1 2009
Externally published	Yes

Keywords

Germ cells
Gonad
Granulosa cells
Leydig cells
Oocyte
Review
Sertoli cells
Spermatogonia
Stem cell
Theca cells

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Cite this

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abstract = "Stem cells have enormous potential for therapeutic application because of their ability to self-renew and differentiate into different cell types. Gonads, which consist of somatic cells and germ cells, are the only organs capable of transmitting genetic materials to the offspring. Germ-line stem cells and somatic stem cells have been found in the testis; however, the presence of stem cells in the ovary remains controversial. In this review, we discuss studies focusing on whether stem cell properties are present in the different cell types of male and female gonads and their implications on stem cell research.",

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AU - Liu, Chia Feng

AU - Barsoum, Ivraym

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AU - Hofmann, Marie Claude

AU - Yao, Humphrey Hung Chang

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N2 - Stem cells have enormous potential for therapeutic application because of their ability to self-renew and differentiate into different cell types. Gonads, which consist of somatic cells and germ cells, are the only organs capable of transmitting genetic materials to the offspring. Germ-line stem cells and somatic stem cells have been found in the testis; however, the presence of stem cells in the ovary remains controversial. In this review, we discuss studies focusing on whether stem cell properties are present in the different cell types of male and female gonads and their implications on stem cell research.

AB - Stem cells have enormous potential for therapeutic application because of their ability to self-renew and differentiate into different cell types. Gonads, which consist of somatic cells and germ cells, are the only organs capable of transmitting genetic materials to the offspring. Germ-line stem cells and somatic stem cells have been found in the testis; however, the presence of stem cells in the ovary remains controversial. In this review, we discuss studies focusing on whether stem cell properties are present in the different cell types of male and female gonads and their implications on stem cell research.

KW - Germ cells

KW - Gonad

KW - Granulosa cells

KW - Leydig cells

KW - Oocyte

KW - Review

KW - Sertoli cells

KW - Spermatogonia

KW - Stem cell

KW - Theca cells

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Stem cell potential of the mammalian gonad

Abstract

Keywords

ASJC Scopus subject areas

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