TY - JOUR
T1 - Stem cell therapy in pain medicine
AU - Han, Yong Hee
AU - Kim, Kyung Hoon
AU - Abdi, Salahadin
AU - Kim, Tae Kyun
N1 - Funding Information:
This work was supported by a 2-year Research Grant of Pusan National University.
Publisher Copyright:
© The Korean Pain Society, 2019.
PY - 2019
Y1 - 2019
N2 - Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or degenerated by disease or aging. Stem cells are defined as undifferentiated cells that have the ability to replicate and differentiate themselves into various tissues cells. Stem cells, commonly encountered in clinical or preclinical stages, are largely classified into embryonic, adult, and induced pluripotent stem cells. Recently, stem cell transplantation has been frequently applied to the treatment of pain as an alternative or promising approach for the treatment of severe osteoarthritis, neuropathic pain, and intractable musculoskeletal pain which do not respond to conventional medicine. The main idea of applying stem cells to neuropathic pain is based on the ability of stem cells to release neurotrophic factors, along with providing a cellular source for replacing the injured neural cells, making them ideal candidates for modulating and possibly reversing intractable neuropathic pain. Even though various differentiation capacities of stem cells are reported, there is not enough knowledge and technique to control the differentiation into desired tissues in vivo. Even though the use of stem cells is still in the very early stages of clinical use and raises complicated ethical problems, the future of stem cells therapies is very bright with the help of accumulating evidence and technology.
AB - Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or degenerated by disease or aging. Stem cells are defined as undifferentiated cells that have the ability to replicate and differentiate themselves into various tissues cells. Stem cells, commonly encountered in clinical or preclinical stages, are largely classified into embryonic, adult, and induced pluripotent stem cells. Recently, stem cell transplantation has been frequently applied to the treatment of pain as an alternative or promising approach for the treatment of severe osteoarthritis, neuropathic pain, and intractable musculoskeletal pain which do not respond to conventional medicine. The main idea of applying stem cells to neuropathic pain is based on the ability of stem cells to release neurotrophic factors, along with providing a cellular source for replacing the injured neural cells, making them ideal candidates for modulating and possibly reversing intractable neuropathic pain. Even though various differentiation capacities of stem cells are reported, there is not enough knowledge and technique to control the differentiation into desired tissues in vivo. Even though the use of stem cells is still in the very early stages of clinical use and raises complicated ethical problems, the future of stem cells therapies is very bright with the help of accumulating evidence and technology.
KW - Adult Stem Cells
KW - Aging
KW - Cell Differentiation
KW - Embryonic Stem Cells
KW - Induced Pluripotent Stem Cells
KW - Musculoskeletal Pain
KW - Nerve Growth Factors
KW - Neuralgia
KW - Osteoarthritis
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U2 - 10.3344/kjp.2019.32.4.245
DO - 10.3344/kjp.2019.32.4.245
M3 - Review article
C2 - 31569916
AN - SCOPUS:85074338727
SN - 2005-9159
VL - 32
SP - 245
EP - 255
JO - Korean Journal of Pain
JF - Korean Journal of Pain
IS - 4
ER -