TY - JOUR
T1 - Stem cell transplantation outcomes in lymphoblastic lymphoma
AU - Brammer, Jonathan E.
AU - Khouri, Issa
AU - Marin, David
AU - Ledesma, Celina
AU - Rondon, Gabriela
AU - Ciurea, Stefan O.
AU - Nieto, Yago
AU - Champlin, Richard E.
AU - Hosing, Chitra
AU - Kebriaei, Partow
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Lymphoblastic lymphoma (LBL) is an aggressive lymphoma pathologically similar to lymphoblastic leukemia, but primarily presents with nodal or extra-medullary involvement. The aim of this study is to describe outcomes of patients undergoing stem cell transplantation (SCT) for LBL compared to historical data. Thirty-nine patients, of which 54% lacked complete remission (CR), received SCT for LBL between 1990 and 2015; 31 allogeneic and eight autologous. Overall survival (OS) and progression free survival (PFS) at three years for the entire cohort was 41%, the cumulative incidence (CI) of non-relapse mortality (NRM) was 18% at one year, and CI relapse mortality was 28% at one-year and 36% at three years; results similar to historical reports. On multivariate analysis, the use of total-body irradiation (TBI) based conditioning and transplantation in CR were independently predictive of OS and PFS. For patients requiring SCT for LBL, CR and TBI-based conditioning prior to allogeneic SCT may provide improved disease control.
AB - Lymphoblastic lymphoma (LBL) is an aggressive lymphoma pathologically similar to lymphoblastic leukemia, but primarily presents with nodal or extra-medullary involvement. The aim of this study is to describe outcomes of patients undergoing stem cell transplantation (SCT) for LBL compared to historical data. Thirty-nine patients, of which 54% lacked complete remission (CR), received SCT for LBL between 1990 and 2015; 31 allogeneic and eight autologous. Overall survival (OS) and progression free survival (PFS) at three years for the entire cohort was 41%, the cumulative incidence (CI) of non-relapse mortality (NRM) was 18% at one year, and CI relapse mortality was 28% at one-year and 36% at three years; results similar to historical reports. On multivariate analysis, the use of total-body irradiation (TBI) based conditioning and transplantation in CR were independently predictive of OS and PFS. For patients requiring SCT for LBL, CR and TBI-based conditioning prior to allogeneic SCT may provide improved disease control.
KW - Allogeneic stem cell transplantation
KW - autologous stem cell transplantation
KW - clinical results
KW - lymphoblastic lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84976320510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976320510&partnerID=8YFLogxK
U2 - 10.1080/10428194.2016.1193860
DO - 10.1080/10428194.2016.1193860
M3 - Article
C2 - 27348707
AN - SCOPUS:84976320510
SN - 1042-8194
VL - 58
SP - 366
EP - 371
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 2
ER -