Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma

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2 Scopus citations

Abstract

A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour, curative radiation with stereotactic body radiation therapy (SBRT) to the right upper lobe primary tumour was planned as patient was deemed not to be a surgical candidate. Repeat imaging with a CT chest 2 months after SBRT demonstrated good local control of the primary disease in the right upper lobe despite rapidly advancing distant metastasis. The patient continues systemic therapy with pembrolizumab, to which she has shown good response.

Original languageEnglish (US)
Article numbere234779
JournalBMJ Case Reports
Volume13
Issue number4
DOIs
StatePublished - Apr 22 2020

Keywords

  • lung cancer (oncology)
  • pathology
  • radiotherapy

ASJC Scopus subject areas

  • General Medicine

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