Stereotactic body radiotherapy for unresectable pancreatic cancer

S. T. Chang; K. A. Goodman; G. P. Yang; A. C. Koong

doi:10.1159/0000106048

Stereotactic body radiotherapy for unresectable pancreatic cancer

S. T. Chang, K. A. Goodman, G. P. Yang, A. C. Koong

Image Guided Cancer Therapy Research Program

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

15 Scopus citations

Abstract

Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.

Original language	English (US)
Title of host publication	IMRT, IGRT, SBRT - Advances in the Treatment Planning and Delivery of Radiotherapy
Editors	John Meyer
Pages	386-394
Number of pages	9
Volume	40
DOIs	https://doi.org/10.1159/0000106048
State	Published - Aug 6 2007

Publication series

Name	Frontiers of Radiation Therapy and Oncology
Volume	40
ISSN (Print)	0071-9676

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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10.1159/0000106048

Cite this

Stereotactic body radiotherapy for unresectable pancreatic cancer. / Chang, S. T.; Goodman, K. A.; Yang, G. P. et al.
IMRT, IGRT, SBRT - Advances in the Treatment Planning and Delivery of Radiotherapy. ed. / John Meyer. Vol. 40 2007. p. 386-394 (Frontiers of Radiation Therapy and Oncology; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.",

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N2 - Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.

AB - Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.

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Stereotactic body radiotherapy for unresectable pancreatic cancer

Abstract

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ASJC Scopus subject areas

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