Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer

Javier Leo; Eleonora Dondossola; Kaitlin J. Basham; Nathaniel R. Wilson; Omar Alhalabi; Jianjun Gao; Katherine C. Kurnit; Michael G. White; Jennifer L. McQuade; Shannon N. Westin; Elizabeth A. Wellberg; Daniel E. Frigo

doi:10.1210/endocr/bqad071

Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer

Javier Leo, Eleonora Dondossola, Kaitlin J. Basham, Nathaniel R. Wilson, Omar Alhalabi, Jianjun Gao, Katherine C. Kurnit, Michael G. White, Jennifer L. McQuade, Shannon N. Westin, Elizabeth A. Wellberg, Daniel E. Frigo

Research output: Contribution to journal › Review article › peer-review

Abstract

The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer. In this mini-review, new roles for AR in other cancer types are discussed as well as their potential for treatment with AR-targeted agents. Our understanding of these additional functions for AR in oncology expand this receptor’s potential as a therapeutic target and will help guide the development of new treatment approaches.

Original language	English (US)
Article number	bqad071
Journal	Endocrinology
Volume	164
Issue number	6
DOIs	https://doi.org/10.1210/endocr/bqad071
State	Published - 2023

Keywords

adrenal cancer
androgen receptor
bladder cancer
breast cancer
endometrial cancer
liver cancer
melanoma
prostate cancer

ASJC Scopus subject areas

Endocrinology

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10.1210/endocr/bqad071

Cite this

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title = "Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer",

abstract = "The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer. In this mini-review, new roles for AR in other cancer types are discussed as well as their potential for treatment with AR-targeted agents. Our understanding of these additional functions for AR in oncology expand this receptor{\textquoteright}s potential as a therapeutic target and will help guide the development of new treatment approaches.",

keywords = "adrenal cancer, androgen receptor, bladder cancer, breast cancer, endometrial cancer, liver cancer, melanoma, prostate cancer",

author = "Javier Leo and Eleonora Dondossola and Basham, {Kaitlin J.} and Wilson, {Nathaniel R.} and Omar Alhalabi and Jianjun Gao and Kurnit, {Katherine C.} and White, {Michael G.} and McQuade, {Jennifer L.} and Westin, {Shannon N.} and Wellberg, {Elizabeth A.} and Frigo, {Daniel E.}",

year = "2023",

doi = "10.1210/endocr/bqad071",

language = "English (US)",

volume = "164",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "The Endocrine Society",

number = "6",

}

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T2 - New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer

AU - Leo, Javier

AU - Dondossola, Eleonora

AU - Basham, Kaitlin J.

AU - Wilson, Nathaniel R.

AU - Alhalabi, Omar

AU - Gao, Jianjun

AU - Kurnit, Katherine C.

AU - White, Michael G.

AU - McQuade, Jennifer L.

AU - Westin, Shannon N.

AU - Wellberg, Elizabeth A.

AU - Frigo, Daniel E.

PY - 2023

Y1 - 2023

N2 - The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer. In this mini-review, new roles for AR in other cancer types are discussed as well as their potential for treatment with AR-targeted agents. Our understanding of these additional functions for AR in oncology expand this receptor’s potential as a therapeutic target and will help guide the development of new treatment approaches.

AB - The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer. In this mini-review, new roles for AR in other cancer types are discussed as well as their potential for treatment with AR-targeted agents. Our understanding of these additional functions for AR in oncology expand this receptor’s potential as a therapeutic target and will help guide the development of new treatment approaches.

KW - adrenal cancer

KW - androgen receptor

KW - bladder cancer

KW - breast cancer

KW - endometrial cancer

KW - liver cancer

KW - melanoma

KW - prostate cancer

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U2 - 10.1210/endocr/bqad071

DO - 10.1210/endocr/bqad071

M3 - Review article

C2 - 37154098

AN - SCOPUS:85163897824

SN - 0013-7227

VL - 164

JO - Endocrinology

JF - Endocrinology

IS - 6

M1 - bqad071

ER -

Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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