Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from Singapore and African-Americans

L. Hou; B. Tu; G. Ling; T. Tang; K. Cao; N. K. Steiner; A. Lazaro; J. Ng; R. J. Hartzman; C. K. Hurley

doi:10.1111/j.1399-0039.2005.00503.x

Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from Singapore and African-Americans

L. Hou, B. Tu, G. Ling, T. Tang, K. Cao, N. K. Steiner, A. Lazaro, J. Ng, R. J. Hartzman, C. K. Hurley

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5′ end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.

Original language	English (US)
Pages (from-to)	66-69
Number of pages	4
Journal	Tissue Antigens
Volume	67
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.2005.00503.x
State	Published - Jan 2006
Externally published	Yes

Keywords

Allele frequency
HLA-B

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.2005.00503.x

Cite this

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title = "Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from Singapore and African-Americans",

abstract = "Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5′ end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.",

keywords = "Allele frequency, HLA-B",

author = "L. Hou and B. Tu and G. Ling and T. Tang and K. Cao and Steiner, {N. K.} and A. Lazaro and J. Ng and Hartzman, {R. J.} and Hurley, {C. K.}",

note = "Funding Information: We would like to thank M. Orlandi, G. Bianchi, D. Forastieri and O. Forchini for their help with the fieldwork, and R. Massa for his support throughout the project. The study was partially financed by a grant from Parco Groane to P. C. and L. F., L. W. holds a Training and Mobility grant from the E.U.",

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doi = "10.1111/j.1399-0039.2005.00503.x",

language = "English (US)",

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AU - Hou, L.

AU - Tu, B.

AU - Ling, G.

AU - Tang, T.

AU - Cao, K.

AU - Steiner, N. K.

AU - Lazaro, A.

AU - Ng, J.

AU - Hartzman, R. J.

AU - Hurley, C. K.

N1 - Funding Information: We would like to thank M. Orlandi, G. Bianchi, D. Forastieri and O. Forchini for their help with the fieldwork, and R. Massa for his support throughout the project. The study was partially financed by a grant from Parco Groane to P. C. and L. F., L. W. holds a Training and Mobility grant from the E.U.

PY - 2006/1

Y1 - 2006/1

N2 - Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5′ end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.

AB - Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5′ end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.

KW - Allele frequency

KW - HLA-B

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Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from Singapore and African-Americans

Abstract

Keywords

ASJC Scopus subject areas

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