TY - JOUR
T1 - Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism
AU - Nilsson, Monique B.
AU - Armaiz Pena, Guillermo N
AU - Takahashi, Rie
AU - Lin, Yvonne G.
AU - Trevino, Jose
AU - Li, Yang
AU - Jennings, Nicholas
AU - Arevalo, Jesusa
AU - Lutgendorf, Susan K.
AU - Gallick, Gary E
AU - Sanguino, Angela M.
AU - Lopez-Berestein, Gabriel
AU - Cole, Steven W.
AU - Sood, Anil K.
PY - 2007/10/12
Y1 - 2007/10/12
N2 - Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but the mechanism(s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression.
AB - Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but the mechanism(s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression.
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U2 - 10.1074/jbc.M611539200
DO - 10.1074/jbc.M611539200
M3 - Article
C2 - 17716980
AN - SCOPUS:35649020314
SN - 0021-9258
VL - 282
SP - 29919
EP - 29926
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 41
ER -