TY - JOUR
T1 - Stressful early life experiences and immune dysregulation across the lifespan
AU - Fagundes, Christopher P.
AU - Glaser, Ronald
AU - Kiecolt-Glaser, Janice K.
N1 - Funding Information:
Work on this paper was supported in part by NIH Grants CA131029, CA126857, the Kathryn & Gilbert Mitchell endowment, the S. Robert Davis endowment, and an American Cancer Society Postdoctoral Fellowship Grant PF-11-007-01-CPPB.
PY - 2013/1
Y1 - 2013/1
N2 - There is considerable evidence that stressful early life events influence a variety of physical health problems later in life. Childhood adversity has been linked to elevated rates of morbidity and mortality from a number of chronic diseases. Immune dysregulation may be one potential pathway that explains this link. In this mini-review, we summarize human studies demonstrating that severe early life stressors have lasting immune consequences. We propose a model outlining potential biobehavioral pathways that explain how early life stressors leave people vulnerable to these maladaptive outcomes. Finally, we suggest ideas for future work to test different aspects of this model.
AB - There is considerable evidence that stressful early life events influence a variety of physical health problems later in life. Childhood adversity has been linked to elevated rates of morbidity and mortality from a number of chronic diseases. Immune dysregulation may be one potential pathway that explains this link. In this mini-review, we summarize human studies demonstrating that severe early life stressors have lasting immune consequences. We propose a model outlining potential biobehavioral pathways that explain how early life stressors leave people vulnerable to these maladaptive outcomes. Finally, we suggest ideas for future work to test different aspects of this model.
KW - Childhood maltreatment
KW - Early adversity
KW - Immune dysregulation
KW - Psychoneuroimmunology
KW - Socioeconomic status
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U2 - 10.1016/j.bbi.2012.06.014
DO - 10.1016/j.bbi.2012.06.014
M3 - Review article
C2 - 22771426
AN - SCOPUS:84870757960
SN - 0889-1591
VL - 27
SP - 8
EP - 12
JO - Brain, behavior, and immunity
JF - Brain, behavior, and immunity
IS - 1
ER -