TY - JOUR
T1 - Structural and maturational covariance in early childhood brain development
AU - Geng, Xiujuan
AU - Li, Gang
AU - Lu, Zhaohua
AU - Gao, Wei
AU - Wang, Li
AU - Shen, Dinggang
AU - Zhu, Hongtu
AU - Gilmore, John H.
N1 - Publisher Copyright:
© The Author 2016.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Brain structural covariance networks (SCNs) composed of regions with correlated variation are altered in neuropsychiatric disease and change with age. Little is known about the development of SCNs in early childhood, a period of rapid cortical growth. We investigated the development of structural and maturational covariance networks, including default, dorsal attention, primary visual and sensorimotor networks in a longitudinal population of 118 children after birth to 2 years old and compared them with intrinsic functional connectivity networks. We found that structural covariance of all networks exhibit strong correlations mostly limited to their seed regions. By Age 2, default and dorsal attention structural networks are much less distributed compared with their functional maps. The maturational covariance maps, however, revealed significant couplings in rates of change between distributed regions, which partially recapitulate their functional networks. The structural and maturational covariance of the primary visual and sensorimotor networks shows similar patterns to the corresponding functional networks. Results indicate that functional networks are in place prior to structural networks, that correlated structural patterns in adultmay arise in part fromcoordinated corticalmaturation, and that regional co-activation in functional networks may guide and refine the maturation of SCNs over childhood development.
AB - Brain structural covariance networks (SCNs) composed of regions with correlated variation are altered in neuropsychiatric disease and change with age. Little is known about the development of SCNs in early childhood, a period of rapid cortical growth. We investigated the development of structural and maturational covariance networks, including default, dorsal attention, primary visual and sensorimotor networks in a longitudinal population of 118 children after birth to 2 years old and compared them with intrinsic functional connectivity networks. We found that structural covariance of all networks exhibit strong correlations mostly limited to their seed regions. By Age 2, default and dorsal attention structural networks are much less distributed compared with their functional maps. The maturational covariance maps, however, revealed significant couplings in rates of change between distributed regions, which partially recapitulate their functional networks. The structural and maturational covariance of the primary visual and sensorimotor networks shows similar patterns to the corresponding functional networks. Results indicate that functional networks are in place prior to structural networks, that correlated structural patterns in adultmay arise in part fromcoordinated corticalmaturation, and that regional co-activation in functional networks may guide and refine the maturation of SCNs over childhood development.
KW - Cortical thickness
KW - Early brain development
KW - Functional connectivity
KW - Maturational covariance
KW - Structural covariance
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U2 - 10.1093/cercor/bhw022
DO - 10.1093/cercor/bhw022
M3 - Article
C2 - 26874184
AN - SCOPUS:85021858506
SN - 1047-3211
VL - 27
SP - 1795
EP - 1807
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 3
ER -