Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex

Eric A. Hendrickson; Joy L. Huffman; John A. Tainer

doi:10.1201/9780849352683-38

Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex

Eric A. Hendrickson, Joy L. Huffman, John A. Tainer

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.

Original language	English (US)
Title of host publication	DNA Damage Recognition
Publisher	CRC Press
Pages	629-684
Number of pages	56
ISBN (Electronic)	9780849352683
ISBN (Print)	9780824759612
DOIs	https://doi.org/10.1201/9780849352683-38
State	Published - Jan 1 2005
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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abstract = "DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.",

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AU - Tainer, John A.

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N2 - DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.

AB - DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.

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Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex

Abstract

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