Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Erin D. Bigler; Tracy J. Abildskov; Barry Eggleston; Brian A. Taylor; David F. Tate; Jo Ann Petrie; Mary R. Newsome; Randall S. Scheibel; Harvey Levin; William C. Walker; Naomi Goodrich-Hunsaker; Nicholas J. Tustison; James R. Stone; Andrew R. Mayer; Timothy D. Duncan; Gerry E. York; Elisabeth A. Wilde

doi:10.1002/mpr.1781

Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Erin D. Bigler, Tracy J. Abildskov, Barry Eggleston, Brian A. Taylor, David F. Tate, Jo Ann Petrie, Mary R. Newsome, Randall S. Scheibel, Harvey Levin, William C. Walker, Naomi Goodrich-Hunsaker, Nicholas J. Tustison, James R. Stone, Andrew R. Mayer, Timothy D. Duncan, Gerry E. York, Elisabeth A. Wilde

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.

Original language	English (US)
Article number	e1781
Journal	International Journal of Methods in Psychiatric Research
Volume	28
Issue number	3
DOIs	https://doi.org/10.1002/mpr.1781
State	Published - Sep 1 2019
Externally published	Yes

Keywords

automated image analysis
cognitive assessment
mild traumatic brain injury
neuroimaging quantification
veterans

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1002/mpr.1781

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Bigler, E. D., Abildskov, T. J., Eggleston, B., Taylor, B. A., Tate, D. F., Petrie, J. A., Newsome, M. R., Scheibel, R. S., Levin, H., Walker, W. C., Goodrich-Hunsaker, N., Tustison, N. J., Stone, J. R., Mayer, A. R., Duncan, T. D., York, G. E., & Wilde, E. A. (2019). Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study. International Journal of Methods in Psychiatric Research, 28(3), Article e1781. https://doi.org/10.1002/mpr.1781

Bigler, ED, Abildskov, TJ, Eggleston, B, Taylor, BA, Tate, DF, Petrie, JA, Newsome, MR, Scheibel, RS, Levin, H, Walker, WC, Goodrich-Hunsaker, N, Tustison, NJ, Stone, JR, Mayer, AR, Duncan, TD, York, GE & Wilde, EA 2019, 'Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study', International Journal of Methods in Psychiatric Research, vol. 28, no. 3, e1781. https://doi.org/10.1002/mpr.1781

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abstract = "Objectives: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.",

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doi = "10.1002/mpr.1781",

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AU - Bigler, Erin D.

AU - Abildskov, Tracy J.

AU - Eggleston, Barry

AU - Taylor, Brian A.

AU - Tate, David F.

AU - Petrie, Jo Ann

AU - Newsome, Mary R.

AU - Scheibel, Randall S.

AU - Levin, Harvey

AU - Walker, William C.

AU - Goodrich-Hunsaker, Naomi

AU - Tustison, Nicholas J.

AU - Stone, James R.

AU - Mayer, Andrew R.

AU - Duncan, Timothy D.

AU - York, Gerry E.

AU - Wilde, Elisabeth A.

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Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Abstract

Keywords

ASJC Scopus subject areas

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