Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes

Pamela M. Thomas; Igor Nasonkin; Hongquan Zhang; Robert F. Gagel; Gilbert J. Cote

doi:10.3109/10425170109047567

Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes

Pamela M. Thomas, Igor Nasonkin, Hongquan Zhang, Robert F. Gagel, Gilbert J. Cote

Endocrine Neoplasia & HD

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We report the cloning, genomic organization and sequence of the mouse α-CALC and β-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the α-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the β-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse α-CGRP was found to be identical to rat α-CGRP, however, β-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.

Original language	English (US)
Pages (from-to)	131-135
Number of pages	5
Journal	Mitochondrial DNA
Volume	12
Issue number	2
DOIs	https://doi.org/10.3109/10425170109047567
State	Published - 2001

Keywords

CGRP
calciotrophic hormones
calcitonin

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.3109/10425170109047567

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title = "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes",

abstract = "We report the cloning, genomic organization and sequence of the mouse α-CALC and β-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the α-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the β-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse α-CGRP was found to be identical to rat α-CGRP, however, β-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.",

keywords = "CGRP, calciotrophic hormones, calcitonin",

author = "Thomas, {Pamela M.} and Igor Nasonkin and Hongquan Zhang and Gagel, {Robert F.} and Cote, {Gilbert J.}",

note = "Funding Information: This work was supported by Public Health Service grant DK-46660 (RFG) and DK-02274 (PMT)",

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T1 - Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes

AU - Thomas, Pamela M.

AU - Nasonkin, Igor

AU - Zhang, Hongquan

AU - Gagel, Robert F.

AU - Cote, Gilbert J.

N1 - Funding Information: This work was supported by Public Health Service grant DK-46660 (RFG) and DK-02274 (PMT)

PY - 2001

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AB - We report the cloning, genomic organization and sequence of the mouse α-CALC and β-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the α-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the β-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse α-CGRP was found to be identical to rat α-CGRP, however, β-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.

KW - CGRP

KW - calciotrophic hormones

KW - calcitonin

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Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes

Abstract

Keywords

ASJC Scopus subject areas

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