TY - JOUR
T1 - Study of cardiovascular autonomic insufficiency in advanced cancer patients
AU - Bruera, E.
AU - Chadwick, S.
AU - Fox, R.
AU - Hanson, J.
AU - MacDonald, N.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - To determine the incidence of cardiovascular autonomic insufficiency (CAI), 43 patients with advanced breast cancer and 20 normal controls were evaluated using electrocardiographic tests (heart rate variation during deep breathing and Valsalva maneuver and upon standing) and clinical tests (blood pressure variation during hand grip tests and upon standing). Nutritional status, tumor mass, Karnofsky performance status (PS) score (0-100), and peripheral reflexes were also determined. Tests for CAI were abnormal in 43 patients (52%), versus seven of 100 in 20 controls (7%, P < 0.001). In cancer patients, tests for CAI were more frequently abnormal in patients with PS < 60 (P < 0.01), basal heart rate > 100 (P = 0.05), and malnutrition (P < 0.01). We conclude that CAI is a frequent finding in patients with advanced breast cancer and should be suspected mainly in patients with a low PS, tachycardia, or malnutrition. It is probably a multifactorial syndrome, and malnutrition, drugs, decreased activity, or paraneoplastic syndromes are all possible causes for CAI.
AB - To determine the incidence of cardiovascular autonomic insufficiency (CAI), 43 patients with advanced breast cancer and 20 normal controls were evaluated using electrocardiographic tests (heart rate variation during deep breathing and Valsalva maneuver and upon standing) and clinical tests (blood pressure variation during hand grip tests and upon standing). Nutritional status, tumor mass, Karnofsky performance status (PS) score (0-100), and peripheral reflexes were also determined. Tests for CAI were abnormal in 43 patients (52%), versus seven of 100 in 20 controls (7%, P < 0.001). In cancer patients, tests for CAI were more frequently abnormal in patients with PS < 60 (P < 0.01), basal heart rate > 100 (P = 0.05), and malnutrition (P < 0.01). We conclude that CAI is a frequent finding in patients with advanced breast cancer and should be suspected mainly in patients with a low PS, tachycardia, or malnutrition. It is probably a multifactorial syndrome, and malnutrition, drugs, decreased activity, or paraneoplastic syndromes are all possible causes for CAI.
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M3 - Article
C2 - 3791252
AN - SCOPUS:0022881221
SN - 0361-5960
VL - 70
SP - 1383
EP - 1387
JO - Cancer Treatment Reports
JF - Cancer Treatment Reports
IS - 12
ER -