Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia

S. Dong; J. Zhu; S. Kuang; J. Qiu; Z. Wang; S. Chen; L. Chen

Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia

S. Dong, J. Zhu, S. Kuang, J. Qiu, Z. Wang, S. Chen, L. Chen

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To explore the role of promyelocytic leukemia zinc finger (PLZF) gene on 11q23 and RARalpha gene on 17q21. METHODS: Eight PLZF/RARalpha expression plasmids with deletions of different PLZF motifs were constructed by using PCR based-method. RESULTS AND CONCLUSION: By transient co-transfection, it was confirmed that PLZF/RARalpha had a dominant negative effect against the wild-type RARalpha, the POZ domain of PLZF/RARalpha was responsible for the dominant negative effect and the PLZF/RARalpha may play certain role through a spatial interaction with POZ.

Original language	English (US)
Pages (from-to)	8-12
Number of pages	5
Journal	Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Volume	18
Issue number	1
State	Published - Jan 1997
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia",

abstract = "OBJECTIVE: To explore the role of promyelocytic leukemia zinc finger (PLZF) gene on 11q23 and RARalpha gene on 17q21. METHODS: Eight PLZF/RARalpha expression plasmids with deletions of different PLZF motifs were constructed by using PCR based-method. RESULTS AND CONCLUSION: By transient co-transfection, it was confirmed that PLZF/RARalpha had a dominant negative effect against the wild-type RARalpha, the POZ domain of PLZF/RARalpha was responsible for the dominant negative effect and the PLZF/RARalpha may play certain role through a spatial interaction with POZ.",

author = "S. Dong and J. Zhu and S. Kuang and J. Qiu and Z. Wang and S. Chen and L. Chen",

year = "1997",

month = jan,

language = "English (US)",

volume = "18",

pages = "8--12",

journal = "Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi",

issn = "0253-2727",

publisher = "Zhongguo Yixue Kexueyuan",

number = "1",

}

TY - JOUR

T1 - Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia

AU - Dong, S.

AU - Zhu, J.

AU - Kuang, S.

AU - Qiu, J.

AU - Wang, Z.

AU - Chen, S.

AU - Chen, L.

PY - 1997/1

Y1 - 1997/1

N2 - OBJECTIVE: To explore the role of promyelocytic leukemia zinc finger (PLZF) gene on 11q23 and RARalpha gene on 17q21. METHODS: Eight PLZF/RARalpha expression plasmids with deletions of different PLZF motifs were constructed by using PCR based-method. RESULTS AND CONCLUSION: By transient co-transfection, it was confirmed that PLZF/RARalpha had a dominant negative effect against the wild-type RARalpha, the POZ domain of PLZF/RARalpha was responsible for the dominant negative effect and the PLZF/RARalpha may play certain role through a spatial interaction with POZ.

AB - OBJECTIVE: To explore the role of promyelocytic leukemia zinc finger (PLZF) gene on 11q23 and RARalpha gene on 17q21. METHODS: Eight PLZF/RARalpha expression plasmids with deletions of different PLZF motifs were constructed by using PCR based-method. RESULTS AND CONCLUSION: By transient co-transfection, it was confirmed that PLZF/RARalpha had a dominant negative effect against the wild-type RARalpha, the POZ domain of PLZF/RARalpha was responsible for the dominant negative effect and the PLZF/RARalpha may play certain role through a spatial interaction with POZ.

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AN - SCOPUS:77951218991

SN - 0253-2727

VL - 18

SP - 8

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JO - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

IS - 1

ER -

Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia

Abstract

ASJC Scopus subject areas

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