TY - JOUR
T1 - Study protocol for the OligoMetastatic Esophagogastric Cancer (OMEC) project
T2 - A multidisciplinary European consensus project on the definition and treatment for oligometastatic esophagogastric cancer
AU - OMEC-working group (Supplementary File 1)
AU - Kroese, Tiuri E.
AU - van Rossum, Peter S.N.
AU - Nilsson, Magnus
AU - Lordick, Florian
AU - Smyth, Elizabeth C.
AU - Rosati, Riccardo
AU - Nafteux, Philippe
AU - D'Ugo, Domenico
AU - Chaudry, M. Asif
AU - Polkowkski, Wojciech
AU - Roviello, Franco
AU - Gockel, Ines
AU - Kolodziejczyk, Piotr
AU - Haustermans, Karin
AU - Guckenberger, Matthias
AU - Nordsmark, Marianne
AU - Hawkins, Maria A.
AU - Cervantes, Andres
AU - Fleitas, Tania
AU - van Cutsem, Eric
AU - Moehler, Markus
AU - Wagner, Anna D.
AU - van Laarhoven, Hanneke W.M.
AU - van Hillegersberg, Richard
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2023/1
Y1 - 2023/1
N2 - Background: A uniform definition and treatment for oligometastatic esophagogastric cancer is currently lacking. However, a comprehensive definition of oligometastatic esophagogastric cancer is necessary to initiate studies on local treatment strategies (e.g. metastasectomy or stereotactic radiotherapy) and new systemic therapy agents in this group of patients. For this purpose, the OligoMetastatic Esophagogastric Cancer (OMEC) project was established. The OMEC-project aims to develop a multidisciplinary European consensus statement on the definition, diagnosis, and treatment for oligometastatic esophagogastric cancer and provide a framework for prospective studies to improve outcomes of these patients. Methods: The OMEC-project consists of five studies, including 1) a systematic review on definitions and outcomes of oligometastatic esophagogastric cancer; 2) real-life clinical scenario discussions in multidisciplinary expert teams to determine the variation in the definition and treatment strategies; 3) Delphi consensus process through a starting meeting, two Delphi questionnaire rounds, and a consensus meeting; 4) publication of a multidisciplinary European consensus statement; and 5) a prospective clinical trial in patients with oligometastatic esophagogastric cancer. Discussion: The OMEC project aims to establish a multidisciplinary European consensus statement for oligometastatic esophagogastric cancer and aims to initiate a prospective clinical trial to improve outcomes for these patients. Recommendations from OMEC can be used to update the relevant guidelines on treatment for patients with (oligometastatic) esophagogastric cancer.
AB - Background: A uniform definition and treatment for oligometastatic esophagogastric cancer is currently lacking. However, a comprehensive definition of oligometastatic esophagogastric cancer is necessary to initiate studies on local treatment strategies (e.g. metastasectomy or stereotactic radiotherapy) and new systemic therapy agents in this group of patients. For this purpose, the OligoMetastatic Esophagogastric Cancer (OMEC) project was established. The OMEC-project aims to develop a multidisciplinary European consensus statement on the definition, diagnosis, and treatment for oligometastatic esophagogastric cancer and provide a framework for prospective studies to improve outcomes of these patients. Methods: The OMEC-project consists of five studies, including 1) a systematic review on definitions and outcomes of oligometastatic esophagogastric cancer; 2) real-life clinical scenario discussions in multidisciplinary expert teams to determine the variation in the definition and treatment strategies; 3) Delphi consensus process through a starting meeting, two Delphi questionnaire rounds, and a consensus meeting; 4) publication of a multidisciplinary European consensus statement; and 5) a prospective clinical trial in patients with oligometastatic esophagogastric cancer. Discussion: The OMEC project aims to establish a multidisciplinary European consensus statement for oligometastatic esophagogastric cancer and aims to initiate a prospective clinical trial to improve outcomes for these patients. Recommendations from OMEC can be used to update the relevant guidelines on treatment for patients with (oligometastatic) esophagogastric cancer.
KW - Esophageal cancer
KW - Gastric cancer
KW - Metastasectomy
KW - Oligometastasis
KW - Radiotherapy
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U2 - 10.1016/j.ejso.2022.09.012
DO - 10.1016/j.ejso.2022.09.012
M3 - Review article
C2 - 36184420
AN - SCOPUS:85139207046
SN - 0748-7983
VL - 49
SP - 21
EP - 28
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 1
ER -