TY - JOUR
T1 - Subclinical haemorrhagic tendency exists in patients with β-thalassaemia major in early childhood
AU - Maiti, Abhishek
AU - Chakraborti, Amartya
AU - Chakraborty, Puranjoy
AU - Mishra, Sanjay
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Background Alterations of coagulation profile have been reported in patients with β-thalassaemia major (β-TM). Method To investigate this in the paediatric population, we studied haemostatic parameters in pre-transfusion blood samples from 50 non-splenectomised transfusion-dependent children with β-TM (mean age 6±2.5 years) and in blood from 25 healthy controls. Results Laboratory evaluation showed thrombocytopenia in 40%, prolongation of prothrombin time (PT) in 12% and prolongation of activated partial thromboplastin time (APTT) in 6% of the patients. Mean values for PT, APTT and platelet count (PC) were all raised in the patient population compared with the controls. The alteration of coagulation status was significant for PT (p value <0.005) and APTT (p value <0.0001). However, the change for PC was not significant (p value >0.05). No significant liner correlation could be identified between PT, APTT, PC of the patients and interval between transfusions (in days) or days since last transfusion. Conclusion The findings from this study suggest that a subclinical haemorrhagic tendency exists in patients with β-TM at a very early age. The intrinsic pathway appears to be more affected than the extrinsic pathway.
AB - Background Alterations of coagulation profile have been reported in patients with β-thalassaemia major (β-TM). Method To investigate this in the paediatric population, we studied haemostatic parameters in pre-transfusion blood samples from 50 non-splenectomised transfusion-dependent children with β-TM (mean age 6±2.5 years) and in blood from 25 healthy controls. Results Laboratory evaluation showed thrombocytopenia in 40%, prolongation of prothrombin time (PT) in 12% and prolongation of activated partial thromboplastin time (APTT) in 6% of the patients. Mean values for PT, APTT and platelet count (PC) were all raised in the patient population compared with the controls. The alteration of coagulation status was significant for PT (p value <0.005) and APTT (p value <0.0001). However, the change for PC was not significant (p value >0.05). No significant liner correlation could be identified between PT, APTT, PC of the patients and interval between transfusions (in days) or days since last transfusion. Conclusion The findings from this study suggest that a subclinical haemorrhagic tendency exists in patients with β-TM at a very early age. The intrinsic pathway appears to be more affected than the extrinsic pathway.
KW - Activated partial thromboplastin time
KW - Coagulation
KW - Haemorrhage
KW - Prothrombin time
KW - Thalassaemia major
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U2 - 10.4066/AMJ.2012.107
DO - 10.4066/AMJ.2012.107
M3 - Article
AN - SCOPUS:84862698085
SN - 1836-1935
VL - 5
SP - 152
EP - 155
JO - Australasian Medical Journal
JF - Australasian Medical Journal
IS - 2
ER -