Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

Naoto T. Ueno; Athanasios Anagnostopoulos; Gabriela Rondón; Richard E. Champlin; N. Mikhailova; O. S. Pankratova; L. S. Zoubarovskaya; E. V. Semenova; B. V. Afanasyev; Susan O'Brien; Michael Andreeff; Andrey Y. Zaritskey

doi:10.1046/j.1365-2141.2002.03771.x

Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

Naoto T. Ueno, Athanasios Anagnostopoulos, Gabriela Rondón, Richard E. Champlin, N. Mikhailova, O. S. Pankratova, L. S. Zoubarovskaya, E. V. Semenova, B. V. Afanasyev, Susan O'Brien, Michael Andreeff, Andrey Y. Zaritskey

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66 Scopus citations

Abstract

In this report, we describe two patients with idiopathic hypereosinophilic syndrome (HES) who received a non-myeloablative allogeneic transplantation following a reduced-intensity preparative regimen of melphalan and fludarabine. In both cases, complete donor chimaerism and remission were achieved, and have lasted for more than 10 months. This report provides proof of principle for the feasibility of non-myeloablative transplantation for patients with idiopathic HES, who can show co-morbidity due to eosinophilic infiltration of their organs.

Original language	English (US)
Pages (from-to)	131-134
Number of pages	4
Journal	British Journal of Haematology
Volume	119
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03771.x
State	Published - 2002

Keywords

Blood and marrow transplantation
Eosinophils
Idiopathic hypereosinophilic syndrome

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2002.03771.x

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Ueno, N. T., Anagnostopoulos, A., Rondón, G., Champlin, R. E., Mikhailova, N., Pankratova, O. S., Zoubarovskaya, L. S., Semenova, E. V., Afanasyev, B. V., O'Brien, S., Andreeff, M., & Zaritskey, A. Y. (2002). Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome. British Journal of Haematology, 119(1), 131-134. https://doi.org/10.1046/j.1365-2141.2002.03771.x

Ueno, NT, Anagnostopoulos, A, Rondón, G , Champlin, RE, Mikhailova, N, Pankratova, OS, Zoubarovskaya, LS, Semenova, EV, Afanasyev, BV, O'Brien, S, Andreeff, M & Zaritskey, AY 2002, 'Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome', British Journal of Haematology, vol. 119, no. 1, pp. 131-134. https://doi.org/10.1046/j.1365-2141.2002.03771.x

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abstract = "In this report, we describe two patients with idiopathic hypereosinophilic syndrome (HES) who received a non-myeloablative allogeneic transplantation following a reduced-intensity preparative regimen of melphalan and fludarabine. In both cases, complete donor chimaerism and remission were achieved, and have lasted for more than 10 months. This report provides proof of principle for the feasibility of non-myeloablative transplantation for patients with idiopathic HES, who can show co-morbidity due to eosinophilic infiltration of their organs.",

keywords = "Blood and marrow transplantation, Eosinophils, Idiopathic hypereosinophilic syndrome",

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AU - Rondón, Gabriela

AU - Champlin, Richard E.

AU - Mikhailova, N.

AU - Pankratova, O. S.

AU - Zoubarovskaya, L. S.

AU - Semenova, E. V.

AU - Afanasyev, B. V.

AU - O'Brien, Susan

AU - Andreeff, Michael

AU - Zaritskey, Andrey Y.

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Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

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Keywords

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