TY - JOUR
T1 - Successful Pregnancy after Intervention for Spindle-Cell Embryonal Rhabdomyosarcoma
T2 - A Case Report
AU - Moufarrij, Sara M.
AU - Edwards, Creighton
AU - McKenzie, Laurie
AU - Adeyemi-Fowode, Oluyemisi
N1 - Publisher Copyright:
© 2020 North American Society for Pediatric and Adolescent Gynecology
PY - 2020/10
Y1 - 2020/10
N2 - Background: Embryonal rhabdomyosarcoma, the most common soft tissue malignancy in childhood, is treated with surgery and chemotherapy. Because of the young age at the time of presentation, a discussion of future reproduction is appropriate and conservative management should be considered. We present a case of embryonal rhabdomyosarcoma that was successfully and conservatively managed with chemotherapy, allowing for future pregnancies. Case: A 17-year-old nulliparous woman with embryonal rhabdomyosarcoma underwent 6 cycles of chemotherapy with adriamycin, dacarbazine, cyclophosphamide, and vincristine, resulting in radiographic resolution of the disease. She was able to conceive without medical intervention and to have successful vaginal deliveries. Summary and Conclusion: The standard of care for embryonal rhabdomyosarcoma is surgery and chemotherapy; however, conservative management should be considered when preservation of fertility is a goal.
AB - Background: Embryonal rhabdomyosarcoma, the most common soft tissue malignancy in childhood, is treated with surgery and chemotherapy. Because of the young age at the time of presentation, a discussion of future reproduction is appropriate and conservative management should be considered. We present a case of embryonal rhabdomyosarcoma that was successfully and conservatively managed with chemotherapy, allowing for future pregnancies. Case: A 17-year-old nulliparous woman with embryonal rhabdomyosarcoma underwent 6 cycles of chemotherapy with adriamycin, dacarbazine, cyclophosphamide, and vincristine, resulting in radiographic resolution of the disease. She was able to conceive without medical intervention and to have successful vaginal deliveries. Summary and Conclusion: The standard of care for embryonal rhabdomyosarcoma is surgery and chemotherapy; however, conservative management should be considered when preservation of fertility is a goal.
KW - Embryonal rhabdomyosarcoma
KW - Fertility preservation
KW - Oncofertility
KW - Pediatrics
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U2 - 10.1016/j.jpag.2020.03.004
DO - 10.1016/j.jpag.2020.03.004
M3 - Article
C2 - 32224250
AN - SCOPUS:85084588258
SN - 1083-3188
VL - 33
SP - 613
EP - 615
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
IS - 5
ER -