TY - JOUR
T1 - 29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe
AU - Kim, Jiwon
AU - Jo, Donghyuk
AU - Yang, Seung Hyun
AU - Joo, Chan Gyu
AU - Whiting, Nicholas
AU - Pudakalakatti, Shivanand
AU - Seo, Hyeonglim
AU - Son, Hye Young
AU - Min, Sun Joon
AU - Bhattacharya, Pratip
AU - Huh, Yong Min
AU - Shim, Jeong Hyun
AU - Lee, Youngbok
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF-2019R1C1C1005412 and NRF-2020R1A4A4079870) and a grant (GP2021-0010) from the Korea Research Institute of Standards and Science.
Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2021/12/8
Y1 - 2021/12/8
N2 - Silicon particles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. However, due to the limited levels of hyperpolarization for nanosized silicon particles, microscale silicon particles have primarily been the focus of dynamic nuclear polarization (DNP) applications, including in vivo magnetic resonance imaging (MRI). To address these current challenges, we developed a facile synthetic method for partially 29Si-enriched porous silicon nanoparticles (NPs) (160 nm) and examined their usability in hyperpolarized 29Si MRI agents with enhanced signals in spectroscopy and imaging. Hyperpolarization characteristics, such as the build-up constant, the depolarization time (T1), and the overall enhancement of the 29Si-enriched silicon NPs (10 and 15%), were thoroughly investigated and compared with those of a naturally abundant NP (4.7%). During optimal DNP conditions, the 15% enriched silicon NPs showed more than 16-fold higher enhancements-far beyond the enrichment ratio-than the naturally abundant sample, further improving the signal-to-noise ratio in in vivo 29Si MRI. The 29Si-enriched porous silicon NPs used in this work are potentially capable to serve as drug-delivery vehicles in addition to hyperpolarized 29Si in vivo, further enabling their potential future applicability as a theragnostic platform.
AB - Silicon particles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. However, due to the limited levels of hyperpolarization for nanosized silicon particles, microscale silicon particles have primarily been the focus of dynamic nuclear polarization (DNP) applications, including in vivo magnetic resonance imaging (MRI). To address these current challenges, we developed a facile synthetic method for partially 29Si-enriched porous silicon nanoparticles (NPs) (160 nm) and examined their usability in hyperpolarized 29Si MRI agents with enhanced signals in spectroscopy and imaging. Hyperpolarization characteristics, such as the build-up constant, the depolarization time (T1), and the overall enhancement of the 29Si-enriched silicon NPs (10 and 15%), were thoroughly investigated and compared with those of a naturally abundant NP (4.7%). During optimal DNP conditions, the 15% enriched silicon NPs showed more than 16-fold higher enhancements-far beyond the enrichment ratio-than the naturally abundant sample, further improving the signal-to-noise ratio in in vivo 29Si MRI. The 29Si-enriched porous silicon NPs used in this work are potentially capable to serve as drug-delivery vehicles in addition to hyperpolarized 29Si in vivo, further enabling their potential future applicability as a theragnostic platform.
KW - hyperpolarization
KW - isotope enrichment
KW - magnetic resonance imaging
KW - nanoimaging
KW - silicon nanoparticles
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U2 - 10.1021/acsami.1c16617
DO - 10.1021/acsami.1c16617
M3 - Article
C2 - 34793118
AN - SCOPUS:85119960039
SN - 1944-8244
VL - 13
SP - 56923
EP - 56930
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 48
ER -