TY - JOUR
T1 - Superoxide dismutase does not cause scar thinning after myocardial infarction
AU - Werns, Steven W.
AU - Shea, Michael J.
AU - Vaporciyan, Ara
AU - Phan, Sem
AU - Abrams, Gerald D.
AU - Buda, Andrew J.
AU - Pitt, Bertram
AU - Lucchesi, Benedict R.
PY - 1987
Y1 - 1987
N2 - Previous studies demonstrated that treatment with superoxide dismutase, a scavenger of superoxide anions, limits the extent of myocardial injury in a canine preparation of regional myocardial ischemia and reperfusion. Little is known, however, about the effects of superoxide dismutase on the healing of a myocardial infarct. Therefore, this study was performed to determine whether treatment with superoxide dismutase during myocardial ischemia impairs formation of scar tissue after infarction. Dogs received 2 hour infusions of superoxide dismutase or albumin (controls) by way of the left atrium beginning 15 minutes before and ending 15 minutes after a 90 minute occlusion of the left circumflex coronary artery. Six weeks later the animals were killed. Two-dimensional echocardiography was performed before surgery and before induced death. Wall thickening in the central ischemic zone was decreased at 6 weeks compared with baseline studies (p < 0.05), but the decrease was similar for both groups. The hydroxyproline concentrations (μg/mg dry weight) of the scar tissue in the superoxide dismutase and control groups, respectively, were 35.3 ± 3.8 and 28.7 ± 5.0 (p < 0.05). The ratios of the scar thickness to normal wall thickness were superoxide dismutase 0.91 ± 0.03 and control 0.89 ± 0.03 (p > 0.05). Thus, superoxide dismutase had no adverse effect on wall thickening or scar formation assessed 6 weeks after myocardial infarction, and may be useful to limit oxygen radical-mediated damage during reperfusion of the ischemic myocardium.
AB - Previous studies demonstrated that treatment with superoxide dismutase, a scavenger of superoxide anions, limits the extent of myocardial injury in a canine preparation of regional myocardial ischemia and reperfusion. Little is known, however, about the effects of superoxide dismutase on the healing of a myocardial infarct. Therefore, this study was performed to determine whether treatment with superoxide dismutase during myocardial ischemia impairs formation of scar tissue after infarction. Dogs received 2 hour infusions of superoxide dismutase or albumin (controls) by way of the left atrium beginning 15 minutes before and ending 15 minutes after a 90 minute occlusion of the left circumflex coronary artery. Six weeks later the animals were killed. Two-dimensional echocardiography was performed before surgery and before induced death. Wall thickening in the central ischemic zone was decreased at 6 weeks compared with baseline studies (p < 0.05), but the decrease was similar for both groups. The hydroxyproline concentrations (μg/mg dry weight) of the scar tissue in the superoxide dismutase and control groups, respectively, were 35.3 ± 3.8 and 28.7 ± 5.0 (p < 0.05). The ratios of the scar thickness to normal wall thickness were superoxide dismutase 0.91 ± 0.03 and control 0.89 ± 0.03 (p > 0.05). Thus, superoxide dismutase had no adverse effect on wall thickening or scar formation assessed 6 weeks after myocardial infarction, and may be useful to limit oxygen radical-mediated damage during reperfusion of the ischemic myocardium.
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U2 - 10.1016/S0735-1097(87)80248-6
DO - 10.1016/S0735-1097(87)80248-6
M3 - Article
C2 - 3558989
AN - SCOPUS:0023129956
SN - 0735-1097
VL - 9
SP - 898
EP - 902
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 4
ER -