TY - JOUR
T1 - Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
AU - Castrillon, Diego H.
AU - Miao, Lili
AU - Kollipara, Ramya
AU - Horner, James W.
AU - DePinho, Ronald A.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/7/11
Y1 - 2003/7/11
N2 - Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stages of follicular growth as a suppressor of follicular activation. In addition to providing a molecular entry point for studying the regulation of follicular growth, these results raise the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.
AB - Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stages of follicular growth as a suppressor of follicular activation. In addition to providing a molecular entry point for studying the regulation of follicular growth, these results raise the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.
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U2 - 10.1126/science.1086336
DO - 10.1126/science.1086336
M3 - Article
C2 - 12855809
AN - SCOPUS:0038152845
SN - 0036-8075
VL - 301
SP - 215
EP - 218
JO - Science
JF - Science
IS - 5630
ER -