Abstract
Serial IGF-1 levels in patients prior to and during adjuvant tamoxifen (TAM) treatment were followed in a retrospective study. Serum IGF-1 levels were determined by radioimmunoassay in 19 patients taking TAM and 19 controls, matched for age, body weight and other treatments. IGF-1 levels at 2 years were significantly lower in TAM patients (P ≤ 0.05) compared to control patients. We observed a significant mean drop from pretreatment to treatment IGF-1 levels by 19.9% in the TAM group (P ≤ 0.005), but also noted a mean 11.4% decline in the control group (P ≤ 0.025). A subgroup analysis suggested that premenopausal were relatively resistant to the IGF-1 lowering effects of TAM as compared to postmenopausal women.
Original language | English (US) |
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Pages (from-to) | 1368-1372 |
Number of pages | 5 |
Journal | European Journal of Cancer |
Volume | 29 |
Issue number | 10 |
DOIs | |
State | Published - 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research