TY - JOUR
T1 - Suppression of Tumor Suppressors in Prostate Cancer
T2 - The Emergence of a Novel Oncogenic Pathway
AU - Thompson, Timothy C.
PY - 2007/11/13
Y1 - 2007/11/13
N2 - Elucidating oncogenic pathways in prostate cancer is an arduous task. In this issue of Cancer Cell, Yu and colleagues show that repression of Adrenergic Receptor Beta-2 gene expression by Enhancer of Zeste 2 results in acquisition of transforming activities. It is interesting that these activities point to a role for GTPases as important regulators of transformation in prostate cancer cells. They further implicate epithelial-mesenchymal transition as a biologic end point in this process. Overall, on the basis of their findings, the authors nominate a novel oncogenic pathway for prostate cancer that deserves critical thought and attention.
AB - Elucidating oncogenic pathways in prostate cancer is an arduous task. In this issue of Cancer Cell, Yu and colleagues show that repression of Adrenergic Receptor Beta-2 gene expression by Enhancer of Zeste 2 results in acquisition of transforming activities. It is interesting that these activities point to a role for GTPases as important regulators of transformation in prostate cancer cells. They further implicate epithelial-mesenchymal transition as a biologic end point in this process. Overall, on the basis of their findings, the authors nominate a novel oncogenic pathway for prostate cancer that deserves critical thought and attention.
UR - http://www.scopus.com/inward/record.url?scp=35748953433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748953433&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2007.10.025
DO - 10.1016/j.ccr.2007.10.025
M3 - Short survey
C2 - 17996641
AN - SCOPUS:35748953433
SN - 1535-6108
VL - 12
SP - 405
EP - 407
JO - Cancer cell
JF - Cancer cell
IS - 5
ER -