Surgical margins analysis with combined confocal microscopy-optical coherence tomography

Nicusor Iftimia; John Grimble; Mark Scimone; Gopi Maguluri; Savitri Krishnamurthy

Surgical margins analysis with combined confocal microscopy-optical coherence tomography

Nicusor Iftimia, John Grimble, Mark Scimone, Gopi Maguluri, Savitri Krishnamurthy

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Successful cancer surgery is achieved when the surgical bed is clear of cancer cells. The standard method to make this determination is to analyze the margins of the excised surgical specimen. Currently, frozen-section analysis (FSA) is the typical procedure for analyzing tissue specimens removed from living patients during surgery. However, FSA is characterized by considerably lower sensitivity compared with the pathologic analysis of paraffin blocks. This leads to positive margins left behind and high rates of cancer recurrence (up to 35%). Here we present a novel instrument for surgical margins analysis based on combined confocal microscopy-optical coherence tomography. Our preliminary study on over 10 surgical specimens shows instrument capability to evaluate surgical margins with high accuracy.

Original language	English (US)
Title of host publication	Microscopy Histopathology and Analytics, Microscopy 2022
Publisher	Optica Publishing Group (formerly OSA)
ISBN (Electronic)	9781557528209
State	Published - 2022
Event	Microscopy Histopathology and Analytics, Microscopy 2022 - Fort Lauderdale, United States Duration: Apr 24 2022 → Apr 27 2022

Publication series

Name	Optics InfoBase Conference Papers

Conference

Conference	Microscopy Histopathology and Analytics, Microscopy 2022
Country/Territory	United States
City	Fort Lauderdale
Period	4/24/22 → 4/27/22

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

Cite this

Surgical margins analysis with combined confocal microscopy-optical coherence tomography. / Iftimia, Nicusor; Grimble, John; Scimone, Mark et al.
Microscopy Histopathology and Analytics, Microscopy 2022. Optica Publishing Group (formerly OSA), 2022. MS2A.5 (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Iftimia, N, Grimble, J, Scimone, M, Maguluri, G & Krishnamurthy, S 2022, Surgical margins analysis with combined confocal microscopy-optical coherence tomography. in Microscopy Histopathology and Analytics, Microscopy 2022., MS2A.5, Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), Microscopy Histopathology and Analytics, Microscopy 2022, Fort Lauderdale, United States, 4/24/22.

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AU - Krishnamurthy, Savitri

PY - 2022

Y1 - 2022

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AB - Successful cancer surgery is achieved when the surgical bed is clear of cancer cells. The standard method to make this determination is to analyze the margins of the excised surgical specimen. Currently, frozen-section analysis (FSA) is the typical procedure for analyzing tissue specimens removed from living patients during surgery. However, FSA is characterized by considerably lower sensitivity compared with the pathologic analysis of paraffin blocks. This leads to positive margins left behind and high rates of cancer recurrence (up to 35%). Here we present a novel instrument for surgical margins analysis based on combined confocal microscopy-optical coherence tomography. Our preliminary study on over 10 surgical specimens shows instrument capability to evaluate surgical margins with high accuracy.

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M3 - Conference contribution

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BT - Microscopy Histopathology and Analytics, Microscopy 2022

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ER -

Surgical margins analysis with combined confocal microscopy-optical coherence tomography

Abstract

Publication series

Conference

ASJC Scopus subject areas

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