TY - JOUR
T1 - Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma
AU - Smythe, W. Roy
AU - Estrera, Anthony L.
AU - Swisher, Stephen G.
AU - Merriman, Kelly W.
AU - Walsh, Garrett L.
AU - Putnam, Joe B.
AU - Vaporciyan, Ara A.
AU - Roth, Jack A.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Background. Development of non-small cell lung carcinoma (NSCLC) in patients previously treated for small cell carcinoma (SCLC/NSCLC) is well described; however, little is known about clinical outcome. Methods. A single-institution 20-year review was performed. Patient characteristics and survival for SCLC/NSCLC patients were compared with those for control patients matched for stage, resection, and previous malignancy. Results. One thousand four hundred four patients with Small cell carcinoma were identified, and 29 underwent therapy for metachronous NSCLC: 11 of 29 patients underwent surgical resection, 10 of these 11 (90%) were stage I. Compared with surgically treated stage I NSCLC patients, SCLC/NSCLC patients were more likely to have squamous histology (70% versus 35%, p = 0.026); and subanatomic resection (90% versus 17.4%, p < 0.0005). The SCLC/NSCLC patients had significantly poorer survival when compared with stage I NSCLC patients undergoing any resection (24,53 versus 74.43 months, p = 0.003) and stage I NSCLC patients receiving wedge resection (24.53 versus 58.39 months, p = 0.006). Survival was similar to NSCLC patients with a history of previous treated extrathoracic solid malignancy. Conclusions. Surgical resection for SCLC/NSCLC patients is feasible, but poorer prognosis is noted when compared with stage-matched control patients. Surgical candidates should be carefully chosen, and alternative local control modalities considered.
AB - Background. Development of non-small cell lung carcinoma (NSCLC) in patients previously treated for small cell carcinoma (SCLC/NSCLC) is well described; however, little is known about clinical outcome. Methods. A single-institution 20-year review was performed. Patient characteristics and survival for SCLC/NSCLC patients were compared with those for control patients matched for stage, resection, and previous malignancy. Results. One thousand four hundred four patients with Small cell carcinoma were identified, and 29 underwent therapy for metachronous NSCLC: 11 of 29 patients underwent surgical resection, 10 of these 11 (90%) were stage I. Compared with surgically treated stage I NSCLC patients, SCLC/NSCLC patients were more likely to have squamous histology (70% versus 35%, p = 0.026); and subanatomic resection (90% versus 17.4%, p < 0.0005). The SCLC/NSCLC patients had significantly poorer survival when compared with stage I NSCLC patients undergoing any resection (24,53 versus 74.43 months, p = 0.003) and stage I NSCLC patients receiving wedge resection (24.53 versus 58.39 months, p = 0.006). Survival was similar to NSCLC patients with a history of previous treated extrathoracic solid malignancy. Conclusions. Surgical resection for SCLC/NSCLC patients is feasible, but poorer prognosis is noted when compared with stage-matched control patients. Surgical candidates should be carefully chosen, and alternative local control modalities considered.
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U2 - 10.1016/S0003-4975(00)02459-0
DO - 10.1016/S0003-4975(00)02459-0
M3 - Article
C2 - 11269481
AN - SCOPUS:0035102517
SN - 0003-4975
VL - 71
SP - 962
EP - 966
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -