TY - JOUR
T1 - Symptom burden of cancer patients
T2 - Validation of the German M. D. Anderson symptom inventory: A cross-sectional multicenter study
AU - Schmidt, Heike
AU - Cleeland, Charles S.
AU - Bauer, Alexander
AU - Landenberger, Margarete
AU - Jahn, Patrick
N1 - Funding Information:
This work was supported in part by ProKID (German Cancer Information Service). The authors declare no conflicts of interest.
Publisher Copyright:
© 2015 American Academy of Hospice and Palliative Medicine.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Context. Cancer patients frequently suffer from various symptoms often impairing functional status and quality of life. To enable timely supportive care, these symptoms must be assessed adequately with reliable tools.Objectives. This study aimed to validate the German version of the M. D. Anderson Symptom Inventory (MDASI).Methods. This was a multicenter, cross-sectional, observational study. At five German university hospitals, 697 cancer patients aged from 18 to 80 years undergoing active anticancer treatment were recruited to participate in the study. For the validation, reliability (Cronbach's alpha), construct validity (factor analysis), known group validity (Eastern Cooperative Oncology Group Performance Status), and convergent divergent analyses were calculated.Results. Of the 980 patients who were eligible, 697 patients were included and agreed to participate in the study (71%). Reliability analysis showed good internal consistencies for the MDASI set of symptoms (Cronbach's alpha coefficient = 0.82; 95% CI = 0.78, 0.84) and for the set of interference items (Cronbach's alpha coefficient = 0.857; 95% CI = 0.484, 0.87). Factor analysis resulted in a one-factor solution (general symptoms; eigenvalue = 4.26) with a psychological (distress and sadness) and a gastrointestinal subscale (nausea and vomiting). Convergent and divergent analyses showed significant correlations between symptom burden and distress and global health-related quality of life (subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 Version 3.0.).Conclusion. The MDASI-German version is a valid tool for measuring patient-reported symptom severity and symptom interference in German cancer patients. It is easily applicable and can be used by German clinicians and researchers for screening and monitoring purposes and the comparison of international data.
AB - Context. Cancer patients frequently suffer from various symptoms often impairing functional status and quality of life. To enable timely supportive care, these symptoms must be assessed adequately with reliable tools.Objectives. This study aimed to validate the German version of the M. D. Anderson Symptom Inventory (MDASI).Methods. This was a multicenter, cross-sectional, observational study. At five German university hospitals, 697 cancer patients aged from 18 to 80 years undergoing active anticancer treatment were recruited to participate in the study. For the validation, reliability (Cronbach's alpha), construct validity (factor analysis), known group validity (Eastern Cooperative Oncology Group Performance Status), and convergent divergent analyses were calculated.Results. Of the 980 patients who were eligible, 697 patients were included and agreed to participate in the study (71%). Reliability analysis showed good internal consistencies for the MDASI set of symptoms (Cronbach's alpha coefficient = 0.82; 95% CI = 0.78, 0.84) and for the set of interference items (Cronbach's alpha coefficient = 0.857; 95% CI = 0.484, 0.87). Factor analysis resulted in a one-factor solution (general symptoms; eigenvalue = 4.26) with a psychological (distress and sadness) and a gastrointestinal subscale (nausea and vomiting). Convergent and divergent analyses showed significant correlations between symptom burden and distress and global health-related quality of life (subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 Version 3.0.).Conclusion. The MDASI-German version is a valid tool for measuring patient-reported symptom severity and symptom interference in German cancer patients. It is easily applicable and can be used by German clinicians and researchers for screening and monitoring purposes and the comparison of international data.
KW - Cancer
KW - M. D. Anderson Symptom Inventory
KW - Validation
KW - symptom burden
UR - http://www.scopus.com/inward/record.url?scp=84919952790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919952790&partnerID=8YFLogxK
U2 - 10.1016/j.jpainsymman.2014.04.007
DO - 10.1016/j.jpainsymman.2014.04.007
M3 - Article
C2 - 24858739
AN - SCOPUS:84919952790
SN - 0885-3924
VL - 49
SP - 117
EP - 125
JO - Journal of pain and symptom management
JF - Journal of pain and symptom management
IS - 1
ER -