TY - JOUR
T1 - Synergistic Antiproliferative Activity of Leukocyte Interferon in Combination with α-Difluoromethylornithine against Human Cells in Culture
AU - Rosenblum, Michael G.
AU - Gutterman, Jordan U.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1984/6/1
Y1 - 1984/6/1
N2 - α-Difluoromethylomithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture. True synergistic antiproliferative activity was observed at 72 hr after continuous exposure. This effect was observed regardless of the ratio of interferon to $aL-difluoro-methylomithine concentrations. Although the mechanisms by which this effect occurs are unknown, these studies provide a rationale for combination clinical trials of $aL-difluoromethylomi-thine with leukocyte interferon.
AB - α-Difluoromethylomithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture. True synergistic antiproliferative activity was observed at 72 hr after continuous exposure. This effect was observed regardless of the ratio of interferon to $aL-difluoro-methylomithine concentrations. Although the mechanisms by which this effect occurs are unknown, these studies provide a rationale for combination clinical trials of $aL-difluoromethylomi-thine with leukocyte interferon.
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M3 - Article
C2 - 6426779
AN - SCOPUS:0021234008
SN - 0008-5472
VL - 44
SP - 2339
EP - 2340
JO - Cancer Research
JF - Cancer Research
IS - 6
ER -