TY - JOUR
T1 - Synthesis and anticancer activity of novel 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles.
AU - Wang, Peng
AU - Liu, Jianzhen
AU - Xing, Hualu
AU - Liu, Yang
AU - Xie, Wencheng
AU - Zhao, Guisen
PY - 2012/6
Y1 - 2012/6
N2 - A new series of 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles were synthesized and evaluated for their anticancer activities. Structures of the compounds were confirmed by spectroscopic methods. Structural modifications were done to improve the antiproliferative activity of compound 1. The results indicated that a benzyloxyl substituent on the C-4 position was better than a methyl substituent on the C-6 position of the indole component. Compounds 10a, 10b, 10g, 10i, 10l, 10n, 10o, and 10p were found to be more active than lead compound 1 in the PC-3 cell line. These compounds may serve as lead candidates in the development of novel chemotherapeutics for cancer treatment.
AB - A new series of 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles were synthesized and evaluated for their anticancer activities. Structures of the compounds were confirmed by spectroscopic methods. Structural modifications were done to improve the antiproliferative activity of compound 1. The results indicated that a benzyloxyl substituent on the C-4 position was better than a methyl substituent on the C-6 position of the indole component. Compounds 10a, 10b, 10g, 10i, 10l, 10n, 10o, and 10p were found to be more active than lead compound 1 in the PC-3 cell line. These compounds may serve as lead candidates in the development of novel chemotherapeutics for cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84871872590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871872590&partnerID=8YFLogxK
U2 - 10.5582/ddt.2012.v6.3.133
DO - 10.5582/ddt.2012.v6.3.133
M3 - Article
C2 - 22890203
AN - SCOPUS:84871872590
SN - 1881-7831
VL - 6
SP - 133
EP - 139
JO - Drug discoveries & therapeutics
JF - Drug discoveries & therapeutics
IS - 3
ER -