Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

Peter Wipf; Stephen M. Lynch; Garth Powis; Anne Birmingham; Erikah E. Englund

doi:10.1039/b510718k

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

Peter Wipf, Stephen M. Lynch, Garth Powis, Anne Birmingham, Erikah E. Englund

Experimental Therapeutics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.

Original language	English (US)
Pages (from-to)	3880-3882
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	3
Issue number	21
DOIs	https://doi.org/10.1039/b510718k
State	Published - Nov 7 2005

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system",

abstract = "A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.",

author = "Peter Wipf and Lynch, {Stephen M.} and Garth Powis and Anne Birmingham and Englund, {Erikah E.}",

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T1 - Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

AU - Wipf, Peter

AU - Lynch, Stephen M.

AU - Powis, Garth

AU - Birmingham, Anne

AU - Englund, Erikah E.

PY - 2005/11/7

Y1 - 2005/11/7

N2 - A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.

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EP - 3882

JO - Organic and Biomolecular Chemistry

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IS - 21

ER -

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

Abstract

ASJC Scopus subject areas

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