Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

Fei Yu; Yazhe Wang; Yu Hang; Weimin Tang; Zhifeng Zhao; David Oupický

doi:10.1002/pola.29512

Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

Fei Yu, Yazhe Wang, Yu Hang, Weimin Tang, Zhifeng Zhao, David Oupický

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report synthesis of nondegradable chloroquine (CQ)-containing N-(2-hydroxyethyl)methacrylamide (HPMA) copolymers (pCQ2) by a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and click chemistry. The ability of the copolymers to inhibit cancer cell migration was compared to our previously reported degradable pCQ1 in breast cancer cells utilizing transwell and wound healing assays. Both cleavable and noncleavable pCQ demonstrated enhanced inhibitory activity when compared with small-molecule CQ. This study validates that pCQ2 functions as a macromolecular inhibitor of cancer cell migration without the need for CQ release and provides support for pCQ as a new class of antimetastatic polymer agents with a possibly unique mechanism of action.

Original language	English (US)
Pages (from-to)	2235-2242
Number of pages	8
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	57
Issue number	22
DOIs	https://doi.org/10.1002/pola.29512
State	Published - Nov 15 2019
Externally published	Yes

Keywords

cancer
chloroquine
click chemistry
invasion
polymer

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/pola.29512

Cite this

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title = "Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration",

abstract = "We report synthesis of nondegradable chloroquine (CQ)-containing N-(2-hydroxyethyl)methacrylamide (HPMA) copolymers (pCQ2) by a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and click chemistry. The ability of the copolymers to inhibit cancer cell migration was compared to our previously reported degradable pCQ1 in breast cancer cells utilizing transwell and wound healing assays. Both cleavable and noncleavable pCQ demonstrated enhanced inhibitory activity when compared with small-molecule CQ. This study validates that pCQ2 functions as a macromolecular inhibitor of cancer cell migration without the need for CQ release and provides support for pCQ as a new class of antimetastatic polymer agents with a possibly unique mechanism of action.",

keywords = "cancer, chloroquine, click chemistry, invasion, polymer",

author = "Fei Yu and Yazhe Wang and Yu Hang and Weimin Tang and Zhifeng Zhao and David Oupick{\'y}",

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day = "15",

doi = "10.1002/pola.29512",

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volume = "57",

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T1 - Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

AU - Yu, Fei

AU - Wang, Yazhe

AU - Hang, Yu

AU - Tang, Weimin

AU - Zhao, Zhifeng

AU - Oupický, David

PY - 2019/11/15

Y1 - 2019/11/15

N2 - We report synthesis of nondegradable chloroquine (CQ)-containing N-(2-hydroxyethyl)methacrylamide (HPMA) copolymers (pCQ2) by a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and click chemistry. The ability of the copolymers to inhibit cancer cell migration was compared to our previously reported degradable pCQ1 in breast cancer cells utilizing transwell and wound healing assays. Both cleavable and noncleavable pCQ demonstrated enhanced inhibitory activity when compared with small-molecule CQ. This study validates that pCQ2 functions as a macromolecular inhibitor of cancer cell migration without the need for CQ release and provides support for pCQ as a new class of antimetastatic polymer agents with a possibly unique mechanism of action.

AB - We report synthesis of nondegradable chloroquine (CQ)-containing N-(2-hydroxyethyl)methacrylamide (HPMA) copolymers (pCQ2) by a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and click chemistry. The ability of the copolymers to inhibit cancer cell migration was compared to our previously reported degradable pCQ1 in breast cancer cells utilizing transwell and wound healing assays. Both cleavable and noncleavable pCQ demonstrated enhanced inhibitory activity when compared with small-molecule CQ. This study validates that pCQ2 functions as a macromolecular inhibitor of cancer cell migration without the need for CQ release and provides support for pCQ as a new class of antimetastatic polymer agents with a possibly unique mechanism of action.

KW - cancer

KW - chloroquine

KW - click chemistry

KW - invasion

KW - polymer

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DO - 10.1002/pola.29512

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 22

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Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

Abstract

Keywords

ASJC Scopus subject areas

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