Abstract
A new series of 1,5-disubstituted indolin-2,3-diones was synthesized and their inhibition of the growth of a human acute promyelocytic leukemia (HL-60) cell line was evaluated. These compounds had promising inhibition of HL-60 cell growth in vitro. Results indicated that compounds with a benzyl substituent at the N-1 position on the indolin-2,3-dione ring had more potent antiproliferative activity than those with a (4-fluorobenzyl) amino-2-oxoethyl substituent at the N-1 position. Among the compounds synthesized, compound 8l inhibited half of cell growth at a concentration of 0.07 μM and compound 8p did so at a concentration of 0.14 μM. These compounds may serve as lead compounds for further optimization in order to develop novel anticancer agents.
Original language | English (US) |
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Pages (from-to) | 110-116 |
Number of pages | 7 |
Journal | Drug discoveries & therapeutics |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2014 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine