Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives

Mariola Siwy; Danuta Sȩk; Botena Kaczmarczyk; Iwona Jaroszewicz; Anna Nasulewicz; Marzena Pelczyñska; Dmitry Nevozhay; Adam Opolski

doi:10.1021/jm0490078

Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives

Mariola Siwy, Danuta Sȩk, Botena Kaczmarczyk, Iwona Jaroszewicz, Anna Nasulewicz, Marzena Pelczyñska, Dmitry Nevozhay, Adam Opolski

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A new series of 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized, The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied, Most of the compounds exhibited antiprolilerative activity in the range of the international criterion for synthetic agents (4 μg/mL) against the MOLT4, L 1210, HL-60, and P388 cell lines chosen for testing.

Original language	English (US)
Pages (from-to)	806-810
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	2
DOIs	https://doi.org/10.1021/jm0490078
State	Published - Jan 26 2006
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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title = "Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives",

abstract = "A new series of 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized, The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied, Most of the compounds exhibited antiprolilerative activity in the range of the international criterion for synthetic agents (4 μg/mL) against the MOLT4, L 1210, HL-60, and P388 cell lines chosen for testing.",

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AU - Siwy, Mariola

AU - Sȩk, Danuta

AU - Kaczmarczyk, Botena

AU - Jaroszewicz, Iwona

AU - Nasulewicz, Anna

AU - Pelczyñska, Marzena

AU - Nevozhay, Dmitry

AU - Opolski, Adam

PY - 2006/1/26

Y1 - 2006/1/26

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AB - A new series of 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized, The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied, Most of the compounds exhibited antiprolilerative activity in the range of the international criterion for synthetic agents (4 μg/mL) against the MOLT4, L 1210, HL-60, and P388 cell lines chosen for testing.

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Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives

Abstract

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