Synthesis and preliminary evaluation of a new chelate N2S4 for use in labeling proteins with metallic radionuclides

Ahmad Najafi; Mian M. Alauddin; Michael E. Siegel; Alan L. Epstein

doi:10.1016/0883-2897(91)90076-W

Synthesis and preliminary evaluation of a new chelate N₂S₄ for use in labeling proteins with metallic radionuclides

Ahmad Najafi, Mian M. Alauddin, Michael E. Siegel, Alan L. Epstein

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The successful attachment of various metallic radionuclides such as ^99mTc to monoclonal antibodies for targeting tumor tissue in vivo depends upon the development and use of suitable bifunctional chelating agents. We have successfully synthesized a new N₂S₄ (compound 4) chelate. This chelate forms a stable complex with ^99mTc and is capable of coupling to different proteins. The N₂S₄ compound is quite stable if kept as a hydrochloride salt and is coupled to antibody under neutral conditions with better than 95% efficiency without the loss of immunoreactivity.

Original language	English (US)
Pages (from-to)	179-185
Number of pages	7
Journal	International Journal of Radiation Applications and Instrumentation.
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0883-2897(91)90076-W
State	Published - 1991

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General Medicine

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abstract = "The successful attachment of various metallic radionuclides such as 99mTc to monoclonal antibodies for targeting tumor tissue in vivo depends upon the development and use of suitable bifunctional chelating agents. We have successfully synthesized a new N2S4 (compound 4) chelate. This chelate forms a stable complex with 99mTc and is capable of coupling to different proteins. The N2S4 compound is quite stable if kept as a hydrochloride salt and is coupled to antibody under neutral conditions with better than 95% efficiency without the loss of immunoreactivity.",

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AU - Alauddin, Mian M.

AU - Siegel, Michael E.

AU - Epstein, Alan L.

PY - 1991

Y1 - 1991

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AB - The successful attachment of various metallic radionuclides such as 99mTc to monoclonal antibodies for targeting tumor tissue in vivo depends upon the development and use of suitable bifunctional chelating agents. We have successfully synthesized a new N2S4 (compound 4) chelate. This chelate forms a stable complex with 99mTc and is capable of coupling to different proteins. The N2S4 compound is quite stable if kept as a hydrochloride salt and is coupled to antibody under neutral conditions with better than 95% efficiency without the loss of immunoreactivity.

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Synthesis and preliminary evaluation of a new chelate N₂S₄ for use in labeling proteins with metallic radionuclides

Abstract

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