@inbook{8192cb68e4bb484fbac79f0897f2b588,
title = "Synthesis of bioreducible polycations with controlled topologies",
abstract = "Bioreducible polycations, which possess disulfide linkages in the backbone, have emerged as promising nucleic acid delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of the genetic material. Further benefits of bioreducible polycations include decreased cytotoxicity due to intracellular reducing environment in the cytoplasm that contains high levels of reducing molecules such as glutathione. Here, we describe the synthesis of bioreducible polycations with emphasis on methods to control their topology.",
keywords = "Bioreducible polycations, Controlled topologies, Michael-addition polymerization, Poly(2-(dimethylamino)ethyl methacrylate, Poly(amido amine)s, Polyethylenimine",
author = "You, {Ye Zi} and Yan, {Jun Jie} and Fei Yu and Yu, {Zhi Qiang} and David Oupicky",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019.",
year = "2019",
doi = "10.1007/978-1-4939-9092-4_2",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "27--38",
booktitle = "Methods in Molecular Biology",
}