Synthesis of biotinylated OSW-1

Ying Kang; Changgang Lou; Kausar Begam Riaz Ahmed; Peng Huang; Zhendong Jin

doi:10.1016/j.bmcl.2009.07.062

Synthesis of biotinylated OSW-1

Ying Kang, Changgang Lou, Kausar Begam Riaz Ahmed, Peng Huang, Zhendong Jin

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.

Original language	English (US)
Pages (from-to)	5166-5168
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2009.07.062
State	Published - Sep 1 2009

Keywords

Biotinylated
Natural product
OSW-1
Saponin
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.07.062

Cite this

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title = "Synthesis of biotinylated OSW-1",

abstract = "OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.",

keywords = "Biotinylated, Natural product, OSW-1, Saponin, Synthesis",

author = "Ying Kang and Changgang Lou and Ahmed, {Kausar Begam Riaz} and Peng Huang and Zhendong Jin",

note = "Funding Information: This work was supported by a Grant (5R21CA105073-02) from the National Institutes Health.",

year = "2009",

month = sep,

day = "1",

doi = "10.1016/j.bmcl.2009.07.062",

language = "English (US)",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis of biotinylated OSW-1

AU - Kang, Ying

AU - Lou, Changgang

AU - Ahmed, Kausar Begam Riaz

AU - Huang, Peng

AU - Jin, Zhendong

N1 - Funding Information: This work was supported by a Grant (5R21CA105073-02) from the National Institutes Health.

PY - 2009/9/1

Y1 - 2009/9/1

N2 - OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.

AB - OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.

KW - Biotinylated

KW - Natural product

KW - OSW-1

KW - Saponin

KW - Synthesis

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DO - 10.1016/j.bmcl.2009.07.062

M3 - Article

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AN - SCOPUS:68349150614

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SP - 5166

EP - 5168

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Synthesis of biotinylated OSW-1

Abstract

Keywords

ASJC Scopus subject areas

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