TY - JOUR
T1 - Syringocystadenocarcinoma papilliferum with transition to areas of squamous differentiation
T2 - A case report and review of the literature
AU - Zhang, Yu Helen
AU - Wang, Wei Lien
AU - Rapini, Ronald P.
AU - Torres-Cabala, Carlos
AU - Prieto, Victor G.
AU - Curry, Jonathan L.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/6
Y1 - 2012/6
N2 - Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm, which is typically located in the head and neck, and perianal area. Very few cases have been reported in the literature. Here, we report a case of SCACP with evident transition to squamous differentiation. A 75-year-old white woman presented with 1-year history of a solitary tender nodule in the left upper arm. Physical examination revealed a single, 1.5 × 1.1-cm, erythematous ulcerated nodule within a background of red patch. Biopsy showed an adnexal carcinoma connected to the epidermis and composed of cystic papillary projections admixed with solid basaloid areas with marked cytologic atypia. The basaloid tumor cells appeared to blend with the squamous component that demonstrated ductal formation, which was highlighted by carcinoembryonic antigen. Tumor cells were reactive for both cytokeratins 5/6 and 7. This case represents SCACP arising from syringocystadenoma papilliferum in the upper arm, with distinct transition to areas of squamous differentiation.
AB - Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm, which is typically located in the head and neck, and perianal area. Very few cases have been reported in the literature. Here, we report a case of SCACP with evident transition to squamous differentiation. A 75-year-old white woman presented with 1-year history of a solitary tender nodule in the left upper arm. Physical examination revealed a single, 1.5 × 1.1-cm, erythematous ulcerated nodule within a background of red patch. Biopsy showed an adnexal carcinoma connected to the epidermis and composed of cystic papillary projections admixed with solid basaloid areas with marked cytologic atypia. The basaloid tumor cells appeared to blend with the squamous component that demonstrated ductal formation, which was highlighted by carcinoembryonic antigen. Tumor cells were reactive for both cytokeratins 5/6 and 7. This case represents SCACP arising from syringocystadenoma papilliferum in the upper arm, with distinct transition to areas of squamous differentiation.
KW - cutaneous adnexal tumor
KW - squamous differentiation
KW - syringocystadenocarcinoma papilliferum
KW - syringocystadenoma papilliferum
UR - http://www.scopus.com/inward/record.url?scp=84862799089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862799089&partnerID=8YFLogxK
U2 - 10.1097/DAD.0b013e318235dd34
DO - 10.1097/DAD.0b013e318235dd34
M3 - Review article
C2 - 22343110
AN - SCOPUS:84862799089
SN - 0193-1091
VL - 34
SP - 428
EP - 433
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 4
ER -