Abstract
The purpose of this study was to generate physical data needed for microdosimetry-based models of proton RBE. Our focus was on the frequency and dose average lineal energies, y F and y D. We report data for proton energies from 0.1 to 100 MeV, for spherical volumes 2-103 nm in diameter. These data were calculated using Geant4-DNA Monte Carlo software. The physics implemented in Geant4-DNA has been extensively tested for this type of calculations but data on y F and y D for protons generated with this code have been very limited. An innovative aspect of our study is that we introduced a straightforward procedure for calculation of y F and y D for polyenergetic beams and presented the data in a format that simplifies these calculations. We compared our data with previous studies that used different Monte Carlo codes and with experimental data.
Original language | English (US) |
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Article number | 215018 |
Journal | Physics in medicine and biology |
Volume | 64 |
Issue number | 21 |
DOIs | |
State | Published - Nov 4 2019 |
Keywords
- Geant4-DNA
- microdosimetry
- proton RBE
- proton therapy
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
MD Anderson CCSG core facilities
- Biostatistics Resource Group