TY - JOUR
T1 - Systemic considerations for the surgical treatment of spinal metastatic disease
T2 - a scoping literature review
AU - AO Spine Knowledge Forum Tumor
AU - MacLean, Mark A.
AU - Touchette, Charles J.
AU - Georgiopoulos, Miltiadis
AU - Brunette-Clément, Tristan
AU - Abduljabbar, Fahad H.
AU - Ames, Christopher P.
AU - Bettegowda, Chetan
AU - Charest-Morin, Raphaele
AU - Dea, Nicolas
AU - Fehlings, Michael G.
AU - Gokaslan, Ziya L.
AU - Goodwin, C. Rory
AU - Laufer, Ilya
AU - Netzer, Cordula
AU - Rhines, Laurence D.
AU - Sahgal, Arjun
AU - Shin, John H.
AU - Sciubba, Daniel M.
AU - Stephens, Byron F.
AU - Fourney, Daryl R.
AU - Weber, Michael H.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - Systemic assessment is a pillar in the neurological, oncological, mechanical, and systemic (NOMS) decision-making framework for the treatment of patients with spinal metastatic disease. Despite this importance, emerging evidence relating systemic considerations to clinical outcomes following surgery for spinal metastatic disease has not been comprehensively summarised. We aimed to conduct a scoping literature review of this broad topic. We searched MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL databases from Jan 1, 2000, to July 31, 2021. 61 articles were included, accounting for a total of 22 335 patients. Preoperative systemic variables negatively associated with postoperative clinical outcomes included demographics (eg, older age [>60 years], Black race, male sex, low or elevated body-mass index, and smoking status), medical comorbidities (eg, cardiac, pulmonary, hepatic, renal, endocrine, vascular, and rheumatological), biochemical abnormalities (eg, hypoalbuminaemia, atypical blood cell counts, and elevated C-reactive protein concentration), low muscle mass, generalised motor weakness (American Spinal Cord Injury Association Impairment Scale grade and Frankel grade) and poor ambulation, reduced performance status, and systemic disease burden. This is the first comprehensive scoping review to broadly summarise emerging evidence relevant to the systemic assessment component of the widely used NOMS framework for spinal metastatic disease decision making. Medical, surgical, and radiation oncologists can consider these findings when prognosticating spinal metastatic disease-related surgical outcomes on the basis of patients’ systemic condition. These factors might inform a shared decision-making approach with patients and their families.
AB - Systemic assessment is a pillar in the neurological, oncological, mechanical, and systemic (NOMS) decision-making framework for the treatment of patients with spinal metastatic disease. Despite this importance, emerging evidence relating systemic considerations to clinical outcomes following surgery for spinal metastatic disease has not been comprehensively summarised. We aimed to conduct a scoping literature review of this broad topic. We searched MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL databases from Jan 1, 2000, to July 31, 2021. 61 articles were included, accounting for a total of 22 335 patients. Preoperative systemic variables negatively associated with postoperative clinical outcomes included demographics (eg, older age [>60 years], Black race, male sex, low or elevated body-mass index, and smoking status), medical comorbidities (eg, cardiac, pulmonary, hepatic, renal, endocrine, vascular, and rheumatological), biochemical abnormalities (eg, hypoalbuminaemia, atypical blood cell counts, and elevated C-reactive protein concentration), low muscle mass, generalised motor weakness (American Spinal Cord Injury Association Impairment Scale grade and Frankel grade) and poor ambulation, reduced performance status, and systemic disease burden. This is the first comprehensive scoping review to broadly summarise emerging evidence relevant to the systemic assessment component of the widely used NOMS framework for spinal metastatic disease decision making. Medical, surgical, and radiation oncologists can consider these findings when prognosticating spinal metastatic disease-related surgical outcomes on the basis of patients’ systemic condition. These factors might inform a shared decision-making approach with patients and their families.
UR - http://www.scopus.com/inward/record.url?scp=85133296917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133296917&partnerID=8YFLogxK
U2 - 10.1016/S1470-2045(22)00126-7
DO - 10.1016/S1470-2045(22)00126-7
M3 - Review article
C2 - 35772464
AN - SCOPUS:85133296917
SN - 1470-2045
VL - 23
SP - e321-e333
JO - The lancet oncology
JF - The lancet oncology
IS - 7
ER -