TY - JOUR
T1 - T Cell-Depleted Stem Cell Transplantation for Adults with High-Risk Acute Lymphoblastic Leukemia
T2 - Long-Term Survival for Patients in First Complete Remission with a Decreased Risk of Graft-versus-Host Disease
AU - Goldberg, Jenna D.
AU - Linker, Alex
AU - Kuk, Deborah
AU - Ratan, Ravin
AU - Jurcic, Joseph
AU - Barker, Juliet N.
AU - Castro-Malaspina, Hugo
AU - Giralt, Sergio
AU - Hsu, Katharine
AU - Jakubowski, Ann A.
AU - Jenq, Robert
AU - Koehne, Guenther
AU - Papadopoulos, Esperanza B.
AU - van den Brink, Marcel R.M.
AU - Young, James W.
AU - Boulad, Farid
AU - Kernan, Nancy A.
AU - O'Reilly, Richard J.
AU - Prockop, Susan E.
AU - Yahalom, Joachim
AU - Heller, Glenn
AU - Perales, Miguel Angel
N1 - Funding Information:
Financial disclosure: Supported in part by National Institutes of Health grant P01 CA23766 . Additional support was also received from When Everyone Survives , Cycle for Survival , the New York Community Trust , and the Experimental Therapeutics Center of Memorial Sloan-Kettering Cancer Center , funded by William H. and Alice Goodwin and the Commonwealth Foundation for Cancer Research (M.P.).
PY - 2013/2
Y1 - 2013/2
N2 - Consolidation with allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a survival benefit to patients with acute lymphoblastic leukemia (ALL). We have previously reported comparable survival and relapse rates after T cell-depleted (TCD) allo-HSCT compared with unmodified transplantations for acute myelogenous leukemia, myelodysplastic syndrome, and non-Hodgkin lymphoma with significantly decreased graft-versus-host disease (GVHD). We performed a 56-patient retrospective study to evaluate TCD allo-HSCT for the treatment of ALL after myeloablative total body irradiation-based therapy. The 2-year and 5-year overall survival rates for patients with ALL after TCD allo-HSCT were 0.39 (95% confidence interval [CI], 0.26-0.52) and 0.32 (95% CI, 0.19-0.44), respectively, and the 2-year and 5-year disease-free survival rates were 0.38 (95% CI, 0.25-0.50) and 0.32 (95% CI, 0.20-0.44). There was a trend toward improved survival of patients who underwent TCD allo-HSCT in first complete remission compared with those who did so in other remission states. The cumulative incidence of grade II-IV acute GVHD at 1 year was 0.20 (95% CI, 0.10-0.31), and no patients developed grade IV acute GVHD. The cumulative incidence of chronic GVHD in 41 evaluable patients at 2 and 5 years was 0.15 (95% CI, 0.04-0.26), and that of extensive chronic GVHD at 2 and 5 years was 0.05 (95% CI, 0-11.6). We demonstrate OS and DFS rates that compare favorably to unmodified allo-HSCT with lower rates of GVHD.
AB - Consolidation with allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a survival benefit to patients with acute lymphoblastic leukemia (ALL). We have previously reported comparable survival and relapse rates after T cell-depleted (TCD) allo-HSCT compared with unmodified transplantations for acute myelogenous leukemia, myelodysplastic syndrome, and non-Hodgkin lymphoma with significantly decreased graft-versus-host disease (GVHD). We performed a 56-patient retrospective study to evaluate TCD allo-HSCT for the treatment of ALL after myeloablative total body irradiation-based therapy. The 2-year and 5-year overall survival rates for patients with ALL after TCD allo-HSCT were 0.39 (95% confidence interval [CI], 0.26-0.52) and 0.32 (95% CI, 0.19-0.44), respectively, and the 2-year and 5-year disease-free survival rates were 0.38 (95% CI, 0.25-0.50) and 0.32 (95% CI, 0.20-0.44). There was a trend toward improved survival of patients who underwent TCD allo-HSCT in first complete remission compared with those who did so in other remission states. The cumulative incidence of grade II-IV acute GVHD at 1 year was 0.20 (95% CI, 0.10-0.31), and no patients developed grade IV acute GVHD. The cumulative incidence of chronic GVHD in 41 evaluable patients at 2 and 5 years was 0.15 (95% CI, 0.04-0.26), and that of extensive chronic GVHD at 2 and 5 years was 0.05 (95% CI, 0-11.6). We demonstrate OS and DFS rates that compare favorably to unmodified allo-HSCT with lower rates of GVHD.
KW - Acute lymphoblastic leukemia
KW - Allogeneic transplantation
KW - T cell depletion
UR - http://www.scopus.com/inward/record.url?scp=84872508758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872508758&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2012.09.003
DO - 10.1016/j.bbmt.2012.09.003
M3 - Article
C2 - 22982534
AN - SCOPUS:84872508758
SN - 1083-8791
VL - 19
SP - 208
EP - 213
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 2
ER -