Abstract
Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).
Original language | English (US) |
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Pages (from-to) | 164-171 |
Number of pages | 8 |
Journal | American journal of clinical pathology |
Volume | 149 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2018 |
Keywords
- B-cell lymphoma
- Diffuse large B-cell lymphoma
- T-LGL leukemia
ASJC Scopus subject areas
- Pathology and Forensic Medicine