TY - JOUR
T1 - T Cytotoxic-1 CD8+ T Cells Are Effector Cells against Pneumocystis in Mice
AU - McAllister, Florencia
AU - Steele, Chad
AU - Zheng, Mingquan
AU - Young, Erana
AU - Shellito, Judd E.
AU - Marrero, Luis
AU - Kolls, Jay K.
PY - 2004/1/15
Y1 - 2004/1/15
N2 - Host defenses are profoundly compromised in HIV-infected hosts due to progressive depletion of CD4+ T lymphocytes. A hallmark of HIV infection is Pneumocystis carinii (PC) pneumonia. Recently, CD8+ T cells, which are recruited to the lung in large numbers in response to PC infection, have been associated with some level of host defense as well as contributing to lung injury in BALB/c mice. In this study, we show that CD8 + T cells that have a T cytotoxic-1 response to PC in BALB/c mice, as determined by secretion of IFN-γ, have in vitro killing activity against PC and effect clearance of the organism in adoptive transfer studies. Moreover, non-T cytotoxic-1 CD8+ T cells lacked in vitro effector activity and contributed to lung injury upon adoptive transfer. This dichotomous response in CD8+ T cell response may in part explain the clinical heterogeneity in the severity of PC pneumonia.
AB - Host defenses are profoundly compromised in HIV-infected hosts due to progressive depletion of CD4+ T lymphocytes. A hallmark of HIV infection is Pneumocystis carinii (PC) pneumonia. Recently, CD8+ T cells, which are recruited to the lung in large numbers in response to PC infection, have been associated with some level of host defense as well as contributing to lung injury in BALB/c mice. In this study, we show that CD8 + T cells that have a T cytotoxic-1 response to PC in BALB/c mice, as determined by secretion of IFN-γ, have in vitro killing activity against PC and effect clearance of the organism in adoptive transfer studies. Moreover, non-T cytotoxic-1 CD8+ T cells lacked in vitro effector activity and contributed to lung injury upon adoptive transfer. This dichotomous response in CD8+ T cell response may in part explain the clinical heterogeneity in the severity of PC pneumonia.
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U2 - 10.4049/jimmunol.172.2.1132
DO - 10.4049/jimmunol.172.2.1132
M3 - Article
C2 - 14707088
AN - SCOPUS:1642454705
SN - 0022-1767
VL - 172
SP - 1132
EP - 1138
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -