Abstract
Background Carcinoma ex pleomorphic adenoma (Ca ex-PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA). Methods We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38-year-old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). Results The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA. Conclusions Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma.
Original language | English (US) |
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Pages (from-to) | E181-E183 |
Journal | Head and Neck |
Volume | 35 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2013 |
Keywords
- comparative genomic hybridizations
- cytogenetic
- myoepithelial Ca ex-PA
- spectral karyotyping
- translocations
ASJC Scopus subject areas
- Otorhinolaryngology