TY - JOUR
T1 - Tails of wonder
T2 - Endocytic-sorting motifs key for exogenous antigen presentation
AU - Lizée, Gregory
AU - Basha, Genc
AU - Jefferies, Wilfred A.
N1 - Funding Information:
We wish to thank Laura A. Johnson for critical reading of the manuscript, as well as the Canadian Institutes of Health Research (CIHR), the National Cancer Institute of Canada (NCIC) and the Canadian Foundation for AIDS Research (CANFAR) for supporting our research.
PY - 2005/3
Y1 - 2005/3
N2 - Antigen-presenting molecules, including MHC I, II and CD1, have central roles in the induction of T cell-mediated immunity against pathogens and tumors and also in the maintenance of tolerance towards self-antigens. The presentation of exogenously derived peptide and lipid antigens to specific T cells by professional antigen-presenting cells (pAPCs) is an essential part of both processes. Exogenous antigen loading takes place mostly within specialized endocytic and phagocytic compartments of pAPCs and targeting of antigen-presenting molecules to these intracellular compartments is mediated by highly conserved cytoplasmic sorting motifs. Recent data have revealed that the cytoplasmic tails of antigen-presenting molecules, by controlling the access of these molecules to exogenously derived antigens, have a crucially important and largely underappreciated role in the generation of tolerance and T-cell mediated immunity.
AB - Antigen-presenting molecules, including MHC I, II and CD1, have central roles in the induction of T cell-mediated immunity against pathogens and tumors and also in the maintenance of tolerance towards self-antigens. The presentation of exogenously derived peptide and lipid antigens to specific T cells by professional antigen-presenting cells (pAPCs) is an essential part of both processes. Exogenous antigen loading takes place mostly within specialized endocytic and phagocytic compartments of pAPCs and targeting of antigen-presenting molecules to these intracellular compartments is mediated by highly conserved cytoplasmic sorting motifs. Recent data have revealed that the cytoplasmic tails of antigen-presenting molecules, by controlling the access of these molecules to exogenously derived antigens, have a crucially important and largely underappreciated role in the generation of tolerance and T-cell mediated immunity.
UR - http://www.scopus.com/inward/record.url?scp=14644390830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644390830&partnerID=8YFLogxK
U2 - 10.1016/j.it.2005.01.005
DO - 10.1016/j.it.2005.01.005
M3 - Review article
C2 - 15745856
AN - SCOPUS:14644390830
SN - 1471-4906
VL - 26
SP - 141
EP - 149
JO - Trends in Immunology
JF - Trends in Immunology
IS - 3
ER -