Targeting aurora kinases in cancer treatment

Kevin R. Kelly; Jeffrey Ecsedy; Devalingam Mahalingam; Steffan T. Nawrocki; Swaminathan Padmanabhan; Francis J. Giles; Jennifer S. Carew

doi:10.2174/138945011798829410

Targeting aurora kinases in cancer treatment

Kevin R. Kelly, Jeffrey Ecsedy, Devalingam Mahalingam, Steffan T. Nawrocki, Swaminathan Padmanabhan, Francis J. Giles, Jennifer S. Carew

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The Aurora family of serine/threonine kinases is essential for chromosome alignment, segregation, centrosomal maturation, mitotic spindle formation, and cytokinesis during mitosis. Their fundamental role in cell cycle regulation and aberrant expression in a broad range of malignancies prompted the development of small molecules that selectively inhibit their activity. Recent studies have revealed new insights into the cellular effects of Aurora kinase inhibition. Moreover, early phase clinical studies have shown that these agents have therapeutic efficacy. In this review, we will outline the functions of Aurora kinases in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora inhibitors in cancer treatment.

Original language	English (US)
Pages (from-to)	2067-2078
Number of pages	12
Journal	Current Drug Targets
Volume	12
Issue number	14
DOIs	https://doi.org/10.2174/138945011798829410
State	Published - Dec 2011
Externally published	Yes

Keywords

Aurora kinase inhibitors
Cancer
Mitosis
Targeted therapy

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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abstract = "The Aurora family of serine/threonine kinases is essential for chromosome alignment, segregation, centrosomal maturation, mitotic spindle formation, and cytokinesis during mitosis. Their fundamental role in cell cycle regulation and aberrant expression in a broad range of malignancies prompted the development of small molecules that selectively inhibit their activity. Recent studies have revealed new insights into the cellular effects of Aurora kinase inhibition. Moreover, early phase clinical studies have shown that these agents have therapeutic efficacy. In this review, we will outline the functions of Aurora kinases in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora inhibitors in cancer treatment.",

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AU - Kelly, Kevin R.

AU - Ecsedy, Jeffrey

AU - Mahalingam, Devalingam

AU - Nawrocki, Steffan T.

AU - Padmanabhan, Swaminathan

AU - Giles, Francis J.

AU - Carew, Jennifer S.

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AB - The Aurora family of serine/threonine kinases is essential for chromosome alignment, segregation, centrosomal maturation, mitotic spindle formation, and cytokinesis during mitosis. Their fundamental role in cell cycle regulation and aberrant expression in a broad range of malignancies prompted the development of small molecules that selectively inhibit their activity. Recent studies have revealed new insights into the cellular effects of Aurora kinase inhibition. Moreover, early phase clinical studies have shown that these agents have therapeutic efficacy. In this review, we will outline the functions of Aurora kinases in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora inhibitors in cancer treatment.

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Targeting aurora kinases in cancer treatment

Abstract

Keywords

ASJC Scopus subject areas

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