Targeting cathepsin G in myeloid leukemia

Gheath Alatrash

doi:10.4161/onci.23442

Targeting cathepsin G in myeloid leukemia

Gheath Alatrash

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and-aberrantly-by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.

Original language	English (US)
Article number	e23442
Journal	OncoImmunology
Volume	2
Issue number	4
DOIs	https://doi.org/10.4161/onci.23442
State	Published - Apr 2013

Keywords

AML
Antigen
Azurophil
Cathepsin G
Granule
Immunotherapy
Leukemia
Myeloid
Protease
Target

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.23442

Cite this

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title = "Targeting cathepsin G in myeloid leukemia",

abstract = "Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and-aberrantly-by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.",

keywords = "AML, Antigen, Azurophil, Cathepsin G, Granule, Immunotherapy, Leukemia, Myeloid, Protease, Target",

author = "Gheath Alatrash",

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AB - Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and-aberrantly-by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.

KW - AML

KW - Antigen

KW - Azurophil

KW - Cathepsin G

KW - Granule

KW - Immunotherapy

KW - Leukemia

KW - Myeloid

KW - Protease

KW - Target

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ER -

Targeting cathepsin G in myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

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