TY - JOUR
T1 - Targeting deubiquitinase USP28 for cancer therapy
AU - Wang, Xiaofang
AU - Liu, Zhiyi
AU - Zhang, Li
AU - Yang, Zhaozhi
AU - Chen, Xingxing
AU - Luo, Jurui
AU - Zhou, Zhirui
AU - Mei, Xin
AU - Yu, Xiaoli
AU - Shao, Zhimin
AU - Feng, Yan
AU - Fu, Shen
AU - Zhang, Zhen
AU - Wei, Dongping
AU - Jia, Lijun
AU - Ma, Jinli
AU - Guo, Xiaomao
N1 - Funding Information:
This work was supported by grants from National Natural Science Foundation of China (No. 81072164, 81372430 and 81402525) and the Program of Shanghai Subject Chief Scientist (No.14XD1401200).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/2/1
Y1 - 2018/2/1
N2 - As one of the most important post-translational modifications, ubiquitination plays versatile roles in cancer-related pathways, and is involved in protein metabolism, cell-cycle progression, apoptosis, and transcription. Counteracting the activities of the E3 ligases, the deubiquitylating enzymes have been suggested as another important mechanism to modulate the ubiquitination process, and are implicated in cancer as well. In this article, we review the emerging roles of USP28 in cancer pathways as revealed by recent studies. We discuss the major mechanisms by which USP28 is involved in the cancer-related pathways, whereby USP28 regulates physiological homeostasis of ubiquitination process, DNA-damage response, and cell cycle during genotoxic stress. We further review the studies where USP28 was targeted for treating multiples cancers including non-small cell lung cancer, breast cancer, intestinal cancers, gliomas, and bladder cancer. As a result, the clinical significance of targeting USP28 for cancer therapy merits further exploration and demonstration.
AB - As one of the most important post-translational modifications, ubiquitination plays versatile roles in cancer-related pathways, and is involved in protein metabolism, cell-cycle progression, apoptosis, and transcription. Counteracting the activities of the E3 ligases, the deubiquitylating enzymes have been suggested as another important mechanism to modulate the ubiquitination process, and are implicated in cancer as well. In this article, we review the emerging roles of USP28 in cancer pathways as revealed by recent studies. We discuss the major mechanisms by which USP28 is involved in the cancer-related pathways, whereby USP28 regulates physiological homeostasis of ubiquitination process, DNA-damage response, and cell cycle during genotoxic stress. We further review the studies where USP28 was targeted for treating multiples cancers including non-small cell lung cancer, breast cancer, intestinal cancers, gliomas, and bladder cancer. As a result, the clinical significance of targeting USP28 for cancer therapy merits further exploration and demonstration.
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U2 - 10.1038/s41419-017-0208-z
DO - 10.1038/s41419-017-0208-z
M3 - Review article
C2 - 29415985
AN - SCOPUS:85041809476
SN - 2041-4889
VL - 9
JO - Cell Death and Disease
JF - Cell Death and Disease
IS - 2
M1 - 186
ER -